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10.1152/ajplung.00458.2016 http://scihub22266oqcxt.onion/10.1152/ajplung.00458.2016 C5407091!5407091!28130263     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Physiol+Lung+Cell+Mol+Physiol 2017 ; 312 (4): L488-99 Nephropedia Template TP {{tp|p=28130263|t=2017. Magnetic resonance imaging of disease progression and resolution in a transgenic mouse model of pulmonary fibrosis |pdf=|usr=}}{{28130263}} gab.com Text Magnetic resonance imaging of disease progression and resolution in a transgenic mouse model of pulmonary fibrosis JO: Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28130263 #FOAvip Pulmonary fibrosis contributes to morbidity and mortality in a range of diseases, and there are no approved therapies for reversing its progression. To understand the mechanisms underlying pulmonary fibrosis and assess potential therapies, mouse models are central to basic and translational research. Unfortunately, metrics commonly used to assess murine pulmonary fibrosis require animals to be grouped and euthanized, increasing experimental difficulty and cost. We examined the ability of magnetic resonance imaging (MRI) to noninvasively assess lung fibrosis progression and resolution in a doxycycline (Dox) regulatable, transgenic mouse model that overexpresses transforming growth factor-? (TGF-?) under control of a lung-epithelial-specific promoter. During 7 wk of Dox treatment, fibrotic lesions were readily observed as high-signal tissue. Mean weighted signal and percent signal volume were found to be the most robust MRI-derived measures of fibrosis, and these metrics correlated significantly with pleural thickness, histology scores, and hydroxyproline content (R?=?0.75?0.89). When applied longitudinally, percent high signal volume increased by 1.5% wk?1 (P < 0.001) and mean weighted signal increased at a rate of 0.0065 wk?1 (P = 0.0062). Following Dox treatment, lesions partially resolved, with percent high signal volume decreasing by ?3.2% wk?1 (P = 0.0034) and weighted mean signal decreasing at ?0.015 wk?1 (P = 0.0028). Additionally, longitudinal MRI revealed dynamic remodeling in a subset of lesions, a previously unobserved behavior in this model. These results demonstrate MRI can noninvasively assess experimental lung fibrosis progression and resolution and provide unique insights into its pathobiology. Twit Text FOAVip Magnetic resonance imaging of disease progression and resolution in a transgenic mouse model of pulmonary fibrosis ????Am J Physiol Lung Cell Mol Physiol http://www.kidney.de/pget.php?&tw=1&pmid=28130263 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28130263 #FOAvip English Wikipedia <ref>{{Cite pmid|28130263}}</ref> Magnetic resonance imaging of disease progression and resolution in a transgenic mouse model of pulmonary fibrosis #MMPMID28130263 Cleveland ZI; Zhou YM; Akinyi TG; Dunn RS; Davidson CR; Guo J; Woods JC; Hardie WD Am J Physiol Lung Cell Mol Physiol 2017[Apr]; 312 (4): L488-99 PMID28130263show ga Pulmonary fibrosis contributes to morbidity and mortality in a range of diseases, and there are no approved therapies for reversing its progression. To understand the mechanisms underlying pulmonary fibrosis and assess potential therapies, mouse models are central to basic and translational research. Unfortunately, metrics commonly used to assess murine pulmonary fibrosis require animals to be grouped and euthanized, increasing experimental difficulty and cost. We examined the ability of magnetic resonance imaging (MRI) to noninvasively assess lung fibrosis progression and resolution in a doxycycline (Dox) regulatable, transgenic mouse model that overexpresses transforming growth factor-? (TGF-?) under control of a lung-epithelial-specific promoter. During 7 wk of Dox treatment, fibrotic lesions were readily observed as high-signal tissue. Mean weighted signal and percent signal volume were found to be the most robust MRI-derived measures of fibrosis, and these metrics correlated significantly with pleural thickness, histology scores, and hydroxyproline content (R?=?0.75?0.89). When applied longitudinally, percent high signal volume increased by 1.5% wk?1 (P < 0.001) and mean weighted signal increased at a rate of 0.0065 wk?1 (P = 0.0062). Following Dox treatment, lesions partially resolved, with percent high signal volume decreasing by ?3.2% wk?1 (P = 0.0034) and weighted mean signal decreasing at ?0.015 wk?1 (P = 0.0028). Additionally, longitudinal MRI revealed dynamic remodeling in a subset of lesions, a previously unobserved behavior in this model. These results demonstrate MRI can noninvasively assess experimental lung fibrosis progression and resolution and provide unique insights into its pathobiology. äMagnetic resonance imaging of disease progression and resolution in a (epmc).pdf DeepDyve Pubget Overpricing