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Association of Endothelial Glycocalyx and Tight and Adherens Junctions With
Severity of Plasma Leakage in Dengue Infection
#MMPMID28453844
Suwarto S
; Sasmono RT
; Sinto R
; Ibrahim E
; Suryamin M
J Infect Dis
2017[Mar]; 215
(6
): 992-999
PMID28453844
show ga
BACKGROUND: The role of vascular endothelial (VE) components in dengue infection
with plasma leakage is unknown. Therefore, we conducted a study to determine the
adjusted association of the endothelial glycocalyx layer (EGL) and tight and
adherens junction markers with plasma leakage. METHODS: A prospective
observational study was conducted at Cipto Mangunkusumo Hospital and Persahabatan
Hospital, Jakarta, Indonesia. Adult dengue patients admitted to the hospital on
the third day of fever from November 2013 through August 2015 were included in
the study. Multiple regression analysis was used to determine the adjusted
association of the VE biomarkers with the severity of the plasma leakage.
RESULTS: A total of 103 dengue-infected patients participated in the study. In
the critical phase, levels of syndecan-1 (odds ratio [OR] = 1.004; 95% confidence
interval [CI] = 1.001-1.007) and chondroitin sulfate (OR = 1.157; 95% CI =
1.025-1.307) had an adjusted association with plasma leakage, whereas levels of
syndecan-1 (OR = 1.004; 95% CI = 1.000-1.008) and claudin-5 (OR = 1.038; 95% CI =
1.004-1.074) had an adjusted association with severe plasma leakage. CONCLUSIONS:
In dengue-infected patients, elevated levels of syndecan-1 and chondroitin
sulfate are strongly associated with plasma leakage, and elevated levels of
syndecan-1 and claudin-5 are strongly associated with severe plasma leakage.
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