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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Genes+(Basel) 2017 ; 8 (4): ä Nephropedia Template TP
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c-MYC?Making Liver Sick: Role of c-MYC in Hepatic Cell Function, Homeostasis and Disease #MMPMID28422055
Zheng K; Cubero FJ; Nevzorova YA
Genes (Basel) 2017[Apr]; 8 (4): ä PMID28422055show ga
Over 35 years ago, c-MYC, a highly pleiotropic transcription factor that regulates hepatic cell function, was identified. In recent years, a considerable increment in the number of publications has significantly shifted the way that the c-MYC function is perceived. Overexpression of c-MYC alters a wide range of roles including cell proliferation, growth, metabolism, DNA replication, cell cycle progression, cell adhesion and differentiation. The purpose of this review is to broaden the understanding of the general functions of c-MYC, to focus on c-MYC-driven pathogenesis in the liver, explain its mode of action under basal conditions and during disease, and discuss efforts to target c-MYC as a plausible therapy for liver disease.