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10.3390/genes8040107 http://scihub22266oqcxt.onion/10.3390/genes8040107 C5406854!5406854!28333115     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Genes+(Basel) 2017 ; 8 (4): ä Nephropedia Template TP {{tp|p=28333115|t=2017. Modeling and Targeting MYC Genes in Childhood Brain Tumors |pdf=|usr=}}{{28333115}} gab.com Text Modeling and Targeting MYC Genes in Childhood Brain Tumors JO: Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28333115 #FOAvip Brain tumors are the second most common group of childhood cancers, accounting for about 20%?25% of all pediatric tumors. Deregulated expression of the MYC family of transcription factors, particularly c-MYC and MYCN genes, has been found in many of these neoplasms, and their expression levels are often correlated with poor prognosis. Elevated c-MYC/MYCN initiates and drives tumorigenesis in many in vivo model systems of pediatric brain tumors. Therefore, inhibition of their oncogenic function is an attractive therapeutic target. In this review, we explore the roles of MYC oncoproteins and their molecular targets during the formation, maintenance, and recurrence of childhood brain tumors. We also briefly summarize recent progress in the development of therapeutic approaches for pharmacological inhibition of MYC activity in these tumors. Twit Text FOAVip Modeling and Targeting MYC Genes in Childhood Brain Tumors ????Genes (Basel) http://www.kidney.de/pget.php?&tw=1&pmid=28333115 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28333115 #FOAvip English Wikipedia <ref>{{Cite pmid|28333115}}</ref> Modeling and Targeting MYC Genes in Childhood Brain Tumors #MMPMID28333115 Hutter S; Bolin S; Weishaupt H; Swartling FJ Genes (Basel) 2017[Apr]; 8 (4): ä PMID28333115show ga Brain tumors are the second most common group of childhood cancers, accounting for about 20%?25% of all pediatric tumors. Deregulated expression of the MYC family of transcription factors, particularly c-MYC and MYCN genes, has been found in many of these neoplasms, and their expression levels are often correlated with poor prognosis. Elevated c-MYC/MYCN initiates and drives tumorigenesis in many in vivo model systems of pediatric brain tumors. Therefore, inhibition of their oncogenic function is an attractive therapeutic target. In this review, we explore the roles of MYC oncoproteins and their molecular targets during the formation, maintenance, and recurrence of childhood brain tumors. We also briefly summarize recent progress in the development of therapeutic approaches for pharmacological inhibition of MYC activity in these tumors. äModeling and Targeting MYC Genes in Childhood Brain Tumors (epmc).pdf DeepDyve Pubget Overpricing