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2017 ; 9
(4
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Long Non-Coding RNAs: Key Regulators of Epithelial-Mesenchymal Transition, Tumour
Drug Resistance and Cancer Stem Cells
#MMPMID28430163
Heery R
; Finn SP
; Cuffe S
; Gray SG
Cancers (Basel)
2017[Apr]; 9
(4
): ä PMID28430163
show ga
Epithelial mesenchymal transition (EMT), the adoption by epithelial cells of a
mesenchymal-like phenotype, is a process co-opted by carcinoma cells in order to
initiate invasion and metastasis. In addition, it is becoming clear that is
instrumental to both the development of drug resistance by tumour cells and in
the generation and maintenance of cancer stem cells. EMT is thus a pivotal
process during tumour progression and poses a major barrier to the successful
treatment of cancer. Non-coding RNAs (ncRNA) often utilize epigenetic programs to
regulate both gene expression and chromatin structure. One type of ncRNA, called
long non-coding RNAs (lncRNAs), has become increasingly recognized as being both
highly dysregulated in cancer and to play a variety of different roles in
tumourigenesis. Indeed, over the last few years, lncRNAs have rapidly emerged as
key regulators of EMT in cancer. In this review, we discuss the lncRNAs that have
been associated with the EMT process in cancer and the variety of molecular
mechanisms and signalling pathways through which they regulate EMT, and finally
discuss how these EMT-regulating lncRNAs impact on both anti-cancer drug
resistance and the cancer stem cell phenotype.