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10.1111/cas.13188 http://scihub22266oqcxt.onion/10.1111/cas.13188 C5406604!5406604!28178388     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Sci 2017 ; 108 (4): 570-3 Nephropedia Template TP {{tp|p=28178388|t=2017. Molecular?targeting therapies against quantitative abnormalities in gene expression with malignant tumors |pdf=|usr=}}{{28178388}} gab.com Text Molecular targeting therapies against quantitative abnormalities in gene expression with malignant tumors JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28178388 #FOAvip Genetic mutations in exons of oncogenes and tumor?suppressor genes causing qualitative abnormalities result in activation of the oncogenes and inactivation of the tumor?suppressor genes, thereby causing cancer. In contrast, we have previously demonstrated that decreases in the RB promoter activity by genetic or epigenetic abnormalities can also cause carcinogenesis. In addition, activation and inactivation of a variety of oncogenes and tumor?suppressor genes finally cause quantitative abnormalities in gene expression. Interestingly, we discovered effective molecular?targeting agents, such as a novel MEK inhibitor, trametinib, by screening for agents upregulating the expression of cyclin?dependent kinase inhibitors. In the present review, we focused on the quantitative abnormalities in gene expression with carcinogenesis, and discuss the importance of normalizing the quantitative abnormalities in gene expression with several molecular?targeting agents. Twit Text FOAVip Molecular targeting therapies against quantitative abnormalities in gene expression with malignant tumors ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28178388 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28178388 #FOAvip English Wikipedia <ref>{{Cite pmid|28178388}}</ref> Molecular?targeting therapies against quantitative abnormalities in gene expression with malignant tumors #MMPMID28178388 Sakai T; Sowa Y Cancer Sci 2017[Apr]; 108 (4): 570-3 PMID28178388show ga Genetic mutations in exons of oncogenes and tumor?suppressor genes causing qualitative abnormalities result in activation of the oncogenes and inactivation of the tumor?suppressor genes, thereby causing cancer. In contrast, we have previously demonstrated that decreases in the RB promoter activity by genetic or epigenetic abnormalities can also cause carcinogenesis. In addition, activation and inactivation of a variety of oncogenes and tumor?suppressor genes finally cause quantitative abnormalities in gene expression. Interestingly, we discovered effective molecular?targeting agents, such as a novel MEK inhibitor, trametinib, by screening for agents upregulating the expression of cyclin?dependent kinase inhibitors. In the present review, we focused on the quantitative abnormalities in gene expression with carcinogenesis, and discuss the importance of normalizing the quantitative abnormalities in gene expression with several molecular?targeting agents. äMolecular?targeting therapies against quantitative abnormalities in ge(epmc).pdf DeepDyve Pubget Overpricing