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A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1293/tox.2017-0006 http://scihub22266oqcxt.onion/10.1293/tox.2017-0006 C5406591!5406591!28458450     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28458450&cmd=llinks): Failed to open stream: HTTP request failed! 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A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy |pdf=|usr=}}{{28458450}} gab.com Text A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy JO: J Toxicol Pathol http://www.kidney.de/pget.php?&tw=1&pmid=28458450 #FOAvip Nonclinical juvenile animal tests perform a valuable role in determining adverse drug effects during periods of organogenesis and/or functional maturation. Developmental anatomic and functional maturation time points are important to consider between juveniles and adults when regarding different organ toxicities in response to drug administration. The kidney is an example of a major organ that has differences in these time points in comparing juveniles to adults and in contrasting humans to laboratory animal species. Toxicologic pathologists, involved in juvenile studies, need to be aware of these time points which are age-related exposure periods of sensitivity to drug toxicity. Age-related developmental anatomic and functional maturation are factors which can affect the way that a drug is absorbed, distributed, metabolized, and excreted (ADME). Changes to any component of ADME may alter drug toxicity resulting in kidney abnormalities, nephrotoxicity, or maturational disorders. Juvenile animal kidneys may either be less resistant or more resistant to known adult nephrotoxic drug effects. Furthermore, drug toxicity observed in juvenile animal kidneys may not always correspond to similar toxicities in humans. Juvenile animal nonclinical toxicology studies targeting the kidneys have to be carefully planned to attain the maximum knowledge from each study. Twit Text FOAVip A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy ????J Toxicol Pathol http://www.kidney.de/pget.php?&tw=1&pmid=28458450 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28458450 #FOAvip English Wikipedia <ref>{{Cite pmid|28458450}}</ref> A brief review of kidney development, maturation, developmental abnormalities, and drug toxicity: juvenile animal relevancy #MMPMID28458450 Seely JC J Toxicol Pathol 2017[Apr]; 30 (2): 125-33 PMID28458450show ga Nonclinical juvenile animal tests perform a valuable role in determining adverse drug effects during periods of organogenesis and/or functional maturation. Developmental anatomic and functional maturation time points are important to consider between juveniles and adults when regarding different organ toxicities in response to drug administration. The kidney is an example of a major organ that has differences in these time points in comparing juveniles to adults and in contrasting humans to laboratory animal species. Toxicologic pathologists, involved in juvenile studies, need to be aware of these time points which are age-related exposure periods of sensitivity to drug toxicity. Age-related developmental anatomic and functional maturation are factors which can affect the way that a drug is absorbed, distributed, metabolized, and excreted (ADME). Changes to any component of ADME may alter drug toxicity resulting in kidney abnormalities, nephrotoxicity, or maturational disorders. Juvenile animal kidneys may either be less resistant or more resistant to known adult nephrotoxic drug effects. Furthermore, drug toxicity observed in juvenile animal kidneys may not always correspond to similar toxicities in humans. Juvenile animal nonclinical toxicology studies targeting the kidneys have to be carefully planned to attain the maximum knowledge from each study. äA brief review of kidney development, maturation, developmental abnorm(epmc).pdf DeepDyve Pubget Overpricing