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10.3389/fimmu.2017.00484 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00484 C5406413!5406413!28496445     free     free     free       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28496445|t=2017. Eosinophils in Autoimmune Diseases |pdf=|usr=}}{{28496445}} gab.com Text Eosinophils in Autoimmune Diseases JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28496445 #FOAvip Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases. In this review, we summarize the function of eosinophils in inflammatory bowel diseases, neuromyelitis optica, bullous pemphigoid, autoimmune myocarditis, primary biliary cirrhosis, eosinophilic granulomatosis with polyangiitis, and other autoimmune diseases. Clinical studies, eosinophil-targeted therapies, and experimental models have contributed to our understanding of the regulation and function of eosinophils in these diseases. By examining the role of eosinophils in autoimmune diseases of different organs, we can identify common pathogenic mechanisms. These include degranulation of cytotoxic granule proteins, induction of antibody-dependent cell-mediated cytotoxicity, release of proteases degrading extracellular matrix, immune modulation through cytokines, antigen presentation, and prothrombotic functions. The association of eosinophilic diseases with autoimmune diseases is also examined, showing a possible increase in autoimmune diseases in patients with eosinophilic esophagitis, hypereosinophilic syndrome, and non-allergic asthma. Finally, we summarize key future research needs. Twit Text FOAVip Eosinophils in Autoimmune Diseases ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28496445 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28496445 #FOAvip English Wikipedia <ref>{{Cite pmid|28496445}}</ref> Eosinophils in Autoimmune Diseases #MMPMID28496445 Diny NL; Rose NR; ?iháková D Front Immunol 2017[]; 8 (ä): ä PMID28496445show ga Eosinophils are multifunctional granulocytes that contribute to initiation and modulation of inflammation. Their role in asthma and parasitic infections has long been recognized. Growing evidence now reveals a role for eosinophils in autoimmune diseases. In this review, we summarize the function of eosinophils in inflammatory bowel diseases, neuromyelitis optica, bullous pemphigoid, autoimmune myocarditis, primary biliary cirrhosis, eosinophilic granulomatosis with polyangiitis, and other autoimmune diseases. Clinical studies, eosinophil-targeted therapies, and experimental models have contributed to our understanding of the regulation and function of eosinophils in these diseases. By examining the role of eosinophils in autoimmune diseases of different organs, we can identify common pathogenic mechanisms. These include degranulation of cytotoxic granule proteins, induction of antibody-dependent cell-mediated cytotoxicity, release of proteases degrading extracellular matrix, immune modulation through cytokines, antigen presentation, and prothrombotic functions. The association of eosinophilic diseases with autoimmune diseases is also examined, showing a possible increase in autoimmune diseases in patients with eosinophilic esophagitis, hypereosinophilic syndrome, and non-allergic asthma. Finally, we summarize key future research needs. äEosinophils in Autoimmune Diseases (epmc).pdf DeepDyve Pubget Overpricing