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10.3389/fimmu.2017.00497 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.00497 C5406409!5406409!28496446     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Front+Immunol 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=28496446|t=2017. Toward an Inclusive, Congruent, and Precise Definition of Autoinflammatory Diseases |pdf=|usr=}}{{28496446}} gab.com Text Toward an Inclusive, Congruent, and Precise Definition of Autoinflammatory Diseases JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28496446 #FOAvip Autoinflammatory disease was introduced as a concept in 1999, demarcating an entirely new group of diseases in clinical, immunological, and conceptual terms. During recent years, the preconditions for the definition of autoinflammatory conditions have changed. This includes the recent discovery of a number of monogenic autoinflammatory conditions with complex phenotypes that combine autoinflammation with defects of the adaptive and/or innate immune system, resulting in the occurrence of infection, autoimmunity, and/or uncontrolled hyperinflammation in addition to autoinflammation. Further, there are strong indications that classical IL-1-driven autoinflammatory diseases are associated with activation of adaptive immunity. As suggested by this development, we are of the opinion that an all-encompassing definition of autoinflammatory diseases should regard autoinflammatory conditions and innate dysregulation as inseparable and integral parts of the immune system as a whole. Hence, in this article, we try to advance the conceptual understanding of autoinflammatory disease by, proposing a modification of the definition by Daniel Kastner et al., which allows for a congruent and precise description of conditions that expand the immunological spectrum of autoinflammatory disease. Twit Text FOAVip Toward an Inclusive, Congruent, and Precise Definition of Autoinflammatory Diseases ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=28496446 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28496446 #FOAvip English Wikipedia <ref>{{Cite pmid|28496446}}</ref> Toward an Inclusive, Congruent, and Precise Definition of Autoinflammatory Diseases #MMPMID28496446 Wekell P; Berg S; Karlsson A; Fasth A Front Immunol 2017[]; 8 (ä): ä PMID28496446show ga Autoinflammatory disease was introduced as a concept in 1999, demarcating an entirely new group of diseases in clinical, immunological, and conceptual terms. During recent years, the preconditions for the definition of autoinflammatory conditions have changed. This includes the recent discovery of a number of monogenic autoinflammatory conditions with complex phenotypes that combine autoinflammation with defects of the adaptive and/or innate immune system, resulting in the occurrence of infection, autoimmunity, and/or uncontrolled hyperinflammation in addition to autoinflammation. Further, there are strong indications that classical IL-1-driven autoinflammatory diseases are associated with activation of adaptive immunity. As suggested by this development, we are of the opinion that an all-encompassing definition of autoinflammatory diseases should regard autoinflammatory conditions and innate dysregulation as inseparable and integral parts of the immune system as a whole. Hence, in this article, we try to advance the conceptual understanding of autoinflammatory disease by, proposing a modification of the definition by Daniel Kastner et al., which allows for a congruent and precise description of conditions that expand the immunological spectrum of autoinflammatory disease. äToward an Inclusive, Congruent, and Precise Definition of Autoinflamma(epmc).pdf DeepDyve Pubget Overpricing