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10.1111/bph.13766 http://scihub22266oqcxt.onion/10.1111/bph.13766 C5406384!5406384!28257144     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 302.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Br+J+Pharmacol 2017 ; 174 (10): 1147-60 Nephropedia Template TP {{tp|p=28257144|t=2017. The anti?hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes?associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy |pdf=|usr=}}{{28257144}} gab.com Text The anti hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy JO: Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=28257144 #FOAvip Background and Purpose: Dihydrotanshinone I (DHI), a lipophilic component of traditional Chinese medicine Salvia miltiorrhiza Bunge, has various therapeutic effects. We investigated the anti?fibrotic effect of DHI and its underlying mechanisms in vitro and in vivo. Experimental Approach: Rats subjected to bile duct ligation (BDL) were treated with DHI (25 mg·kg?1·day?1, i.p.) for 14 days. Serum biochemical and liver tissue morphological analyses were performed. The human hepatic stellate cell line LX?2 served as a liver fibrosis model in vitro. Liver fibrogenic genes, yes?associated protein (YAP) downstream genes and autophagy markers were examined using western blot and real?time PCR analyses. Similar analyses were done in rat primary hepatic stellate cells (pHSCs). Autophagy flux was assessed by immunofluorescence. Key Results: In BDL rats, DHI administration attenuated liver necrosis, bile duct proliferation and collagen accumulation and reduced the expression of genes associated with fibrogenesis, including Tgfb1, Mmp?2, Acta2 and Col1a1. DHI (1, 5, 10 ?mol·L?1) time? and dose?dependently suppressed the protein level of COL1A1, TGF?1 and ??SMA in LX?2 cells and rat pHSCs. Furthermore, DHI blocked the nuclear translocation of YAP, which inhibited the YAP/TEAD2 interaction and its downstream fibrogenic genes, connective tissue growth factor, SOX4 and survivin. This stimulated autophagic flux and accelerated the degradation of liver collagen. Conclusions and Implications: DHI exerts anti?fibrotic effects in BDL rats, LX?2 cells and rat pHSCs by inhibiting the YAP and TEAD2 complex and stimulating autophagy. These findings indicate that DHI may be a potential therapeutic for the treatment of liver fibrosis. Twit Text FOAVip The anti hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy ????Br J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=28257144 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28257144 #FOAvip English Wikipedia <ref>{{Cite pmid|28257144}}</ref> The anti?hepatic fibrosis effects of dihydrotanshinone I are mediated by disrupting the yes?associated protein and transcriptional enhancer factor D2 complex and stimulating autophagy #MMPMID28257144 Ge M; Liu H; Zhang Y; Li N; Zhao S; Zhao W; Zhen Y; Yu J; He H; Shao R Br J Pharmacol 2017[May]; 174 (10): 1147-60 PMID28257144show ga Background and Purpose: Dihydrotanshinone I (DHI), a lipophilic component of traditional Chinese medicine Salvia miltiorrhiza Bunge, has various therapeutic effects. We investigated the anti?fibrotic effect of DHI and its underlying mechanisms in vitro and in vivo. Experimental Approach: Rats subjected to bile duct ligation (BDL) were treated with DHI (25 mg·kg?1·day?1, i.p.) for 14 days. Serum biochemical and liver tissue morphological analyses were performed. The human hepatic stellate cell line LX?2 served as a liver fibrosis model in vitro. Liver fibrogenic genes, yes?associated protein (YAP) downstream genes and autophagy markers were examined using western blot and real?time PCR analyses. Similar analyses were done in rat primary hepatic stellate cells (pHSCs). Autophagy flux was assessed by immunofluorescence. Key Results: In BDL rats, DHI administration attenuated liver necrosis, bile duct proliferation and collagen accumulation and reduced the expression of genes associated with fibrogenesis, including Tgfb1, Mmp?2, Acta2 and Col1a1. DHI (1, 5, 10 ?mol·L?1) time? and dose?dependently suppressed the protein level of COL1A1, TGF?1 and ??SMA in LX?2 cells and rat pHSCs. Furthermore, DHI blocked the nuclear translocation of YAP, which inhibited the YAP/TEAD2 interaction and its downstream fibrogenic genes, connective tissue growth factor, SOX4 and survivin. This stimulated autophagic flux and accelerated the degradation of liver collagen. Conclusions and Implications: DHI exerts anti?fibrotic effects in BDL rats, LX?2 cells and rat pHSCs by inhibiting the YAP and TEAD2 complex and stimulating autophagy. These findings indicate that DHI may be a potential therapeutic for the treatment of liver fibrosis. äThe anti?hepatic fibrosis effects of dihydrotanshinone I are mediated (epmc).pdf DeepDyve Pubget Overpricing