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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Medicine+(Baltimore)
2017 ; 96
(16
): e6646
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The use of anticoagulants for prevention and treatment of osteonecrosis of the
femoral head: A systematic review
#MMPMID28422866
Guo P
; Gao F
; Wang Y
; Zhang Z
; Sun W
; Jiang B
; Wang B
; Li Z
Medicine (Baltimore)
2017[Apr]; 96
(16
): e6646
PMID28422866
show ga
BACKGROUND: Osteonecrosis of the femoral head (ONFH) is a progressive disease,
which mainly affects young adults and often necessitates total hip arthroplasty
(THA), so early interventions are critical to successfully protect hip joint from
THA. In this review, our purpose was to determine the effects of anticoagulants
for preventing and treating the primary and secondary ONFH, respectively, before
the collapse stage or before the pathology of necrosis. METHODS: We searched
PubMed, Embase, Web of Science databases for relevant studies. Any observational
or experimental studies that evaluated anticoagulants and ONFH were our goal of
searching the electric databases. RESULTS: Four studies including a total of 218
hips were identified in this review, 2 of them were prospective studies which
performed by 1 group, 1 was a retrospective study, and the last was a prospective
comparative study. CONCLUSIONS: Our findings supported that the anticoagulants
could be used for primary ONFH. However, anticoagulants cannot play a protective
role on secondary ONFH. Moreover, there were no serious adverse effects reported
in the studies after anticoagulants treatment. Nevertheless, our present study
with some limitations such as the limited sample size only provided limited
quality of evidence; confirmation from further systematic review or meta-analysis
with large-scale, well-designed randomized control trials is required.
|Anticoagulants/administration & dosage/*therapeutic use
[MESH]
|Femur Head Necrosis/*drug therapy/physiopathology
[MESH]
free
free
free
