Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1371/journal.ppat.1006326 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1006326 C5406035!5406035!28410401     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       PLoS+Pathog 2017 ; 13 (4): ä Nephropedia Template TP {{tp|p=28410401|t=2017. RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection |pdf=|usr=}}{{28410401}} gab.com Text RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=28410401 #FOAvip The type I interferon pathway plays a critical role in both host defense and tolerance against viral infection and thus requires refined regulatory mechanisms. RIPK3-mediated necroptosis has been shown to be involved in anti-viral immunity. However, the exact role of RIPK3 in immunity to Influenza A Virus (IAV) is poorly understood. In line with others, we, herein, show that Ripk3-/- mice are highly susceptible to IAV infection, exhibiting elevated pulmonary viral load and heightened morbidity and mortality. Unexpectedly, this susceptibility was linked to an inability of RIKP3-deficient macrophages (M?) to produce type I IFN in the lungs of infected mice. In M? infected with IAV in vitro, we found that RIPK3 regulates type I IFN both transcriptionally, by interacting with MAVS and limiting RIPK1 interaction with MAVS, and post-transcriptionally, by activating protein kinase R (PKR)?a critical regulator of IFN-? mRNA stability. Collectively, our findings indicate a novel role for RIPK3 in regulating M?-mediated type I IFN anti-viral immunity, independent of its conventional role in necroptosis. Twit Text FOAVip RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=28410401 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28410401 #FOAvip English Wikipedia <ref>{{Cite pmid|28410401}}</ref> RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection #MMPMID28410401 Downey J; Pernet E; Coulombe F; Allard B; Meunier I; Jaworska J; Qureshi S; Vinh DC; Martin JG; Joubert P; Divangahi M PLoS Pathog 2017[Apr]; 13 (4): ä PMID28410401show ga The type I interferon pathway plays a critical role in both host defense and tolerance against viral infection and thus requires refined regulatory mechanisms. RIPK3-mediated necroptosis has been shown to be involved in anti-viral immunity. However, the exact role of RIPK3 in immunity to Influenza A Virus (IAV) is poorly understood. In line with others, we, herein, show that Ripk3-/- mice are highly susceptible to IAV infection, exhibiting elevated pulmonary viral load and heightened morbidity and mortality. Unexpectedly, this susceptibility was linked to an inability of RIKP3-deficient macrophages (M?) to produce type I IFN in the lungs of infected mice. In M? infected with IAV in vitro, we found that RIPK3 regulates type I IFN both transcriptionally, by interacting with MAVS and limiting RIPK1 interaction with MAVS, and post-transcriptionally, by activating protein kinase R (PKR)?a critical regulator of IFN-? mRNA stability. Collectively, our findings indicate a novel role for RIPK3 in regulating M?-mediated type I IFN anti-viral immunity, independent of its conventional role in necroptosis. äRIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to (epmc).pdf DeepDyve Pubget Overpricing