Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1002/eji.201142343 http://scihub22266oqcxt.onion/10.1002/eji.201142343 C5405866!5405866!23042080     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2013 ; 43 (1): 194-208 Nephropedia Template TP {{tp|p=23042080|t=2013. Syntaxin 11 is required for NK and CD8+ T-cell cytotoxicity and neutrophil degranulation |pdf=|usr=}}{{23042080}} gab.com Text Syntaxin 11 is required for NK and CD8+ T-cell cytotoxicity and neutrophil degranulation JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23042080 #FOAvip Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a Familial Hemophagocytic Lymphohistiocytosis (FHL-4), we wanted to clarify whether STX11 is functionally important for key immune cell populations. This was studied in primary cells obtained from newly generated Stx11-/- mice. Our data revealed that STX11 is not only widely expressed in different immune cells, but also induced upon LPS or IFN-? treatment. However, Stx11 deficiency does not affect macrophage phagocytic function and cytokine secretion, mast cell activation, or antigen presentation by DC. Instead, STX11 selectively controls lymphocyte cytotoxicity in NK and activated CD8+ T cells and degranulation in neutrophils. Stx11-/- NK cells and CTL show impaired degranulation, despite a comparable activation, maturation and expression of the complex-forming partners MUNC18-2 and VTI1B. In addition, Stx11-/- CTL and NK cells produce abnormal levels of IFN-?. Since functional reconstitution rescues the defective phenotype of Stx11-/- CTL we suggest a direct, specific and key role of STX11 in controlling lymphocyte cytotoxicity, cytokine production and secretion. Finally, we show that these mice are a very useful tool for dissecting the role of STX11 in vesicular trafficking and secretion. Twit Text FOAVip Syntaxin 11 is required for NK and CD8+ T-cell cytotoxicity and neutrophil degranulation ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=23042080 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23042080 #FOAvip English Wikipedia <ref>{{Cite pmid|23042080}}</ref> Syntaxin 11 is required for NK and CD8+ T-cell cytotoxicity and neutrophil degranulation #MMPMID23042080 D?Orlando O; Zhao F; Kasper B; Orinska Z; Müller J; Hermans-Borgmeyer I; Griffiths GM; Zur Stadt U; Bulfone-Paus S Eur J Immunol 2013[Jan]; 43 (1): 194-208 PMID23042080show ga Syntaxin 11 (STX11) controls vesicular trafficking and is a key player in exocytosis. Since Stx11 mutations are causally associated with a Familial Hemophagocytic Lymphohistiocytosis (FHL-4), we wanted to clarify whether STX11 is functionally important for key immune cell populations. This was studied in primary cells obtained from newly generated Stx11-/- mice. Our data revealed that STX11 is not only widely expressed in different immune cells, but also induced upon LPS or IFN-? treatment. However, Stx11 deficiency does not affect macrophage phagocytic function and cytokine secretion, mast cell activation, or antigen presentation by DC. Instead, STX11 selectively controls lymphocyte cytotoxicity in NK and activated CD8+ T cells and degranulation in neutrophils. Stx11-/- NK cells and CTL show impaired degranulation, despite a comparable activation, maturation and expression of the complex-forming partners MUNC18-2 and VTI1B. In addition, Stx11-/- CTL and NK cells produce abnormal levels of IFN-?. Since functional reconstitution rescues the defective phenotype of Stx11-/- CTL we suggest a direct, specific and key role of STX11 in controlling lymphocyte cytotoxicity, cytokine production and secretion. Finally, we show that these mice are a very useful tool for dissecting the role of STX11 in vesicular trafficking and secretion. äSyntaxin 11 is required for NK and CD8+ T-cell cytotoxicity and neutro(epmc).pdf DeepDyve Pubget Overpricing