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2017 ; 6
(ä): 390
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Cardiovascular involvement and manifestations of systemic Chikungunya virus
infection: A systematic review
#MMPMID28503297
Alvarez MF
; Bolívar-Mejía A
; Rodriguez-Morales AJ
; Ramirez-Vallejo E
F1000Res
2017[]; 6
(ä): 390
PMID28503297
show ga
BACKGROUND: In the last three years, chikungunya virus disease has been
spreading, affecting particularly the Americas, producing more than two million
cases. In this setting, not only new disease-related epidemiological patterns
have been found, but also new clinical findings have been reported by different
research groups. These include findings on the cardiovascular system, including
clinical, electrocardiographic and echocardiographic alterations. No previous
systemic reviews have been found in major databases about it. METHODS: We
performed a systematic review looking for reports about cardiovascular compromise
during chikungunya disease. Cardiac compromise is not so common in isolated
episodes; but countries where chikungunya virus is an epidemic should be well
informed about this condition. We used 6 bibliographical databases as resources:
Medline/Pubmed, Embase, ScienceDirect, ClinicalKey, Ovid and SciELO. Dengue
reports on cardiovascular compromise were included as well, to compare both
arbovirus' organic compromises. Articles that delved mainly into the rheumatic
articular and cutaneous complications were not considered, as they were not in
line with the purpose of this study. The type of articles included were reviews,
meta-analyses, case-controls, cohort studies, case reports and case series. This
systematic review does not reach or performed a meta-analysis. RESULTS:
Originally based on 737 articles, our reviewed selected 40 articles with 54.2% at
least mentioning CHIKV cardiovascular compromise within the systemic compromise.
Cardiovascular manifestations can be considered common and have been reported in
France, India, Sri Lanka, Malaysia, Colombia, Venezuela and USA, including
mainly, but no limited to: hypotension, shock and circulatory collapse, Raynaud
phenomenon, arrhythmias, murmurs, myocarditis, dilated cardiomyopathy, congestive
insufficiency, heart failure and altered function profile (Troponins, CPK).
CONCLUSIONS: Physicians should be encouraged to keep divulgating reports on the
cardiovascular involvement of chikungunya virus disease, to raise awareness and
ultimately encourage suitable diagnosis and intervention worldwide. More research
about cardiovascular involvement and manifestations of systemic Chikungunya virus
infection is urgently needed.