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10.1186/s12882-017-0561-2

http://scihub22266oqcxt.onion/10.1186/s12882-017-0561-2
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C5405476!5405476!28446143
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suck abstract from ncbi


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pmid28446143      BMC+Nephrol 2017 ; 18 (ä): ä
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  • IgG4-related membranous glomerulonephritis and generalized lymphadenopathy without pancreatitis: a case report #MMPMID28446143
  • Huart J; Grosch S; Bovy C; Moutschen M; Krzesinski JM
  • BMC Nephrol 2017[]; 18 (ä): ä PMID28446143show ga
  • Background: IgG4-related disease is a recently described pathologic entity. This is the case of a patient with nephrotic syndrome and lymphadenopathy due to IgG4-related disease. Such a kidney involvement is quite peculiar and has only been described a few times recently. Renal biopsy showed a glomerular involvement with membranous glomerulonephritis in association with a tubulo-interstitial nephropathy. Moreover, the patient was not suffering from pancreatitis. Case presentation: The patient is a middle-aged man of Moroccan origin. He has developed recurrent episodes of diffuse lymphadenopathies, renal failure and nephrotic syndrome. Renal biopsies showed membranous glomerulonephritis. Discussion and conclusion: The diagnostic approach of this atypical presentation is discussed in this case report as well as diagnostic criteria, therapeutic strategies, biomarkers and pathophysiology of IgG4-related disease. IgG4-related membranous glomerulonephritis is a well-established cause of membranous glomerulonephritis. It must be sought after in every patient with a previous diagnosis of IgG4-related disease and in every patient with this histological finding on renal biopsy. Corticoids are still the first-line treatment of IgG4-related disease. New therapeutic strategies are needed to avoid glucocorticoids long term side-effects. Interestingly, the patient was prescribed cyclophosphamide in addition to glucocorticoids for an immune thrombocytopenia. This treatment had a very good impact on his IgG4-related disease.
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