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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Microcirculation 2017 ; 24 (3): ä Nephropedia Template TP
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Neutrophil-Mediated Vascular Barrier Injury: Role of Neutrophil Extracellular Traps #MMPMID28120468
Meegan JE; Yang X; Coleman DC; Jannaway M; Yuan SY
Microcirculation 2017[Apr]; 24 (3): ä PMID28120468show ga
Neutrophils play an essential role in host defense against infection or injury. While neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive response can lead to tissue damage and microcirculatory disorders, a process involving complex neutrophil-endothelium crosstalk. This review highlights recent research findings about neutrophil-mediated signaling and structural changes, including those induced by neutrophil extracellular traps, which ultimately lead to vascular barrier injury.