Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1111/micc.12364 http://scihub22266oqcxt.onion/10.1111/micc.12364 C5404961!5404961!28231612     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Microcirculation 2017 ; 24 (3): ä Nephropedia Template TP {{tp|p=28231612|t=2017. The pro-inflammatory cytokine TNF-? inhibits lymphatic pumping via activation of the NF-?B - iNOS signaling pathway |pdf=|usr=}}{{28231612}} gab.com Text The pro-inflammatory cytokine TNF- inhibits lymphatic pumping via activation of the NF- B - iNOS signaling pathway JO: Microcirculation http://www.kidney.de/pget.php?&tw=1&pmid=28231612 #FOAvip Objective: Mesenteric lymphatic vessels pumping, important to propel lymph and immune cells from the intestinal interstitium to the mesenteric lymph nodes, is compromised during intestinal inflammation. The objective of this study was to test the hypothesis that the pro-inflammatory cytokine tumor necrosis factor alpha (TNF-?), is a significant contributor to the inflammation-induced lymphatic contractile dysfunction, and to determine its mode of action. Methods: Contractile parameters were obtained form isolated rat mesenteric lymphatic vessels mounted on a pressure myograph after 24-h incubation with or without TNF-?. Various inhibitors were administered and quantitative real-time PCR, western blotting and immunofluorescence confocal imaging were applied to characterize the mechanisms involved in TNF-? actions. Results: Vessel contraction frequency was significantly decreased after TNF-? treatment and could be restored by selective inhibition of NF-?B, iNOS, guanylate cyclase and ATP-sensitive K+ channels. We further demonstrated that NF-?B inhibition also suppressed the significant increase in iNOS mRNA observed in TNF-?-treated lymphatic vessels and that TNF-? treatment favor the nuclear translocation of the p65 NF-?B subunit. Conclusions: These findings suggest that TNF-? decreases mesenteric lymphatic contractility by activating the NF-?B - iNOS signaling pathway. This mechanism could contribute to the alteration of lymphatic pumping reported in intestinal inflammation. Twit Text FOAVip The pro-inflammatory cytokine TNF- inhibits lymphatic pumping via activation of the NF- B - iNOS signaling pathway ????Microcirculation http://www.kidney.de/pget.php?&tw=1&pmid=28231612 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28231612 #FOAvip English Wikipedia <ref>{{Cite pmid|28231612}}</ref> The pro-inflammatory cytokine TNF-? inhibits lymphatic pumping via activation of the NF-?B - iNOS signaling pathway #MMPMID28231612 Chen Y; Rehal S; Roizes S; Zhu HL; Cole WC; von der Weid PY Microcirculation 2017[Apr]; 24 (3): ä PMID28231612show ga Objective: Mesenteric lymphatic vessels pumping, important to propel lymph and immune cells from the intestinal interstitium to the mesenteric lymph nodes, is compromised during intestinal inflammation. The objective of this study was to test the hypothesis that the pro-inflammatory cytokine tumor necrosis factor alpha (TNF-?), is a significant contributor to the inflammation-induced lymphatic contractile dysfunction, and to determine its mode of action. Methods: Contractile parameters were obtained form isolated rat mesenteric lymphatic vessels mounted on a pressure myograph after 24-h incubation with or without TNF-?. Various inhibitors were administered and quantitative real-time PCR, western blotting and immunofluorescence confocal imaging were applied to characterize the mechanisms involved in TNF-? actions. Results: Vessel contraction frequency was significantly decreased after TNF-? treatment and could be restored by selective inhibition of NF-?B, iNOS, guanylate cyclase and ATP-sensitive K+ channels. We further demonstrated that NF-?B inhibition also suppressed the significant increase in iNOS mRNA observed in TNF-?-treated lymphatic vessels and that TNF-? treatment favor the nuclear translocation of the p65 NF-?B subunit. Conclusions: These findings suggest that TNF-? decreases mesenteric lymphatic contractility by activating the NF-?B - iNOS signaling pathway. This mechanism could contribute to the alteration of lymphatic pumping reported in intestinal inflammation. äThe pro-inflammatory cytokine TNF-? inhibits lymphatic pumping via act(epmc).pdf DeepDyve Pubget Overpricing