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10.7554/eLife.22058 http://scihub22266oqcxt.onion/10.7554/eLife.22058 C5404917!5404917!28440748     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       eLife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28440748|t=2017. Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis |pdf=|usr=}}{{28440748}} gab.com Text Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis JO: eLife http://www.kidney.de/pget.php?&tw=1&pmid=28440748 #FOAvip SCP1 as a nuclear transcriptional regulator acts globally to silence neuronal genes and to affect the dephosphorylation of RNA Pol ll. However, we report the first finding and description of SCP1 as a plasma membrane-localized protein in various cancer cells using EGFP- or other epitope-fused SCP1. Membrane-located SCP1 dephosphorylates AKT at serine 473, leading to the abolishment of serine 473 phosphorylation that results in suppressed angiogenesis and a decreased risk of tumorigenesis. Consistently, we observed increased AKT phosphorylation and angiogenesis followed by enhanced tumorigenesis in Ctdsp1 (which encodes SCP1) gene - knockout mice. Importantly, we discovered that the membrane localization of SCP1 is crucial for impeding angiogenesis and tumor growth, and this localization depends on palmitoylation of a conserved cysteine motif within its NH2 terminus. Thus, our study discovers a novel mechanism underlying SCP1 shuttling between the plasma membrane and nucleus, which constitutes a unique pathway in transducing AKT signaling that is closely linked to angiogenesis and tumorigenesis.DOI:http://dx.doi.org/10.7554/eLife.22058.001 Twit Text FOAVip Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis ????eLife http://www.kidney.de/pget.php?&tw=1&pmid=28440748 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28440748 #FOAvip English Wikipedia <ref>{{Cite pmid|28440748}}</ref> Palmitoylated SCP1 is targeted to the plasma membrane and negatively regulates angiogenesis #MMPMID28440748 Liao P; Wang W; Li Y; Wang R; Jin J; Pang W; Chen Y; Shen M; Wang X; Jiang D; Pang J; Liu M; Lin X; Feng XH; Wang P; Ge X eLife 2017[]; 6 (ä): ä PMID28440748show ga SCP1 as a nuclear transcriptional regulator acts globally to silence neuronal genes and to affect the dephosphorylation of RNA Pol ll. However, we report the first finding and description of SCP1 as a plasma membrane-localized protein in various cancer cells using EGFP- or other epitope-fused SCP1. Membrane-located SCP1 dephosphorylates AKT at serine 473, leading to the abolishment of serine 473 phosphorylation that results in suppressed angiogenesis and a decreased risk of tumorigenesis. Consistently, we observed increased AKT phosphorylation and angiogenesis followed by enhanced tumorigenesis in Ctdsp1 (which encodes SCP1) gene - knockout mice. Importantly, we discovered that the membrane localization of SCP1 is crucial for impeding angiogenesis and tumor growth, and this localization depends on palmitoylation of a conserved cysteine motif within its NH2 terminus. Thus, our study discovers a novel mechanism underlying SCP1 shuttling between the plasma membrane and nucleus, which constitutes a unique pathway in transducing AKT signaling that is closely linked to angiogenesis and tumorigenesis.DOI:http://dx.doi.org/10.7554/eLife.22058.001 äPalmitoylated SCP1 is targeted to the plasma membrane and negatively r(epmc).pdf DeepDyve Pubget Overpricing