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10.1189/jlb.2A0215-050RR http://scihub22266oqcxt.onion/10.1189/jlb.2A0215-050RR C5404712!5404712 !26590149     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26590149 &cmd=llinks): Failed to open stream: HTTP request failed! 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WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts |pdf=|usr=}}{{26590149 }} gab.com Text WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts JO: J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=26590149 #FOAvip The immunological synapse is a highly structured and molecularly dynamic interface between communicating immune cells. Although the immunological synapse promotes T cell activation by dendritic cells, the specific organization of the immunological synapse on the dendritic cell side in response to T cell engagement is largely unknown. In this study, confocal and electron microscopy techniques were used to investigate the role of dendritic cell actin regulation in immunological synapse formation, stabilization, and function. In the dendritic cell-restricted absence of the Wiskott-Aldrich syndrome protein, an important regulator of the actin cytoskeleton in hematopoietic cells, the immunological synapse contact with T cells occupied a significantly reduced surface area. At a molecular level, the actin network localized to the immunological synapse exhibited reduced stability, in particular, of the actin-related protein-2/3-dependent, short-filament network. This was associated with decreased polarization of dendritic cell-associated ICAM-1 and MHC class II, which was partially dependent on Wiskott-Aldrich syndrome protein phosphorylation. With the use of supported planar lipid bilayers incorporating anti-ICAM-1 and anti-MHC class II antibodies, the dendritic cell actin cytoskeleton organized into recognizable synaptic structures but interestingly, formed Wiskott-Aldrich syndrome protein-dependent podosomes within this area. These findings demonstrate that intrinsic dendritic cell cytoskeletal remodeling is a key regulatory component of normal immunological synapse formation, likely through consolidation of adhesive interaction and modulation of immunological synapse stability. Twit Text FOAVip WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts ????J Leukoc Biol http://www.kidney.de/pget.php?&tw=1&pmid=26590149 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26590149 #FOAvip English Wikipedia <ref>{{Cite pmid|26590149 }}</ref> WASp-dependent actin cytoskeleton stability at the dendritic cell immunological synapse is required for extensive, functional T cell contacts #MMPMID26590149 Malinova D ; Fritzsche M ; Nowosad CR ; Armer H ; Munro PM ; Blundell MP ; Charras G ; Tolar P ; Bouma G ; Thrasher AJ J Leukoc Biol 2016[May]; 99 (5 ): 699-710 PMID26590149 show ga The immunological synapse is a highly structured and molecularly dynamic interface between communicating immune cells. Although the immunological synapse promotes T cell activation by dendritic cells, the specific organization of the immunological synapse on the dendritic cell side in response to T cell engagement is largely unknown. In this study, confocal and electron microscopy techniques were used to investigate the role of dendritic cell actin regulation in immunological synapse formation, stabilization, and function. In the dendritic cell-restricted absence of the Wiskott-Aldrich syndrome protein, an important regulator of the actin cytoskeleton in hematopoietic cells, the immunological synapse contact with T cells occupied a significantly reduced surface area. At a molecular level, the actin network localized to the immunological synapse exhibited reduced stability, in particular, of the actin-related protein-2/3-dependent, short-filament network. This was associated with decreased polarization of dendritic cell-associated ICAM-1 and MHC class II, which was partially dependent on Wiskott-Aldrich syndrome protein phosphorylation. With the use of supported planar lipid bilayers incorporating anti-ICAM-1 and anti-MHC class II antibodies, the dendritic cell actin cytoskeleton organized into recognizable synaptic structures but interestingly, formed Wiskott-Aldrich syndrome protein-dependent podosomes within this area. These findings demonstrate that intrinsic dendritic cell cytoskeletal remodeling is a key regulatory component of normal immunological synapse formation, likely through consolidation of adhesive interaction and modulation of immunological synapse stability. |Actin Cytoskeleton/*metabolism [MESH] |Animals [MESH] |Cell Communication/*immunology [MESH] |Dendritic Cells/*immunology [MESH] |Fluorescence Recovery After Photobleaching [MESH] |Immunological Synapses/*metabolism [MESH] |Intercellular Adhesion Molecule-1/metabolism [MESH] |Lipid Bilayers/metabolism [MESH] |Lymphocyte Activation/immunology [MESH] |Mice, Inbred C57BL [MESH] |Podosomes/metabolism [MESH] |T-Lymphocytes/*cytology/*immunology [MESH]WASp-dependent actin cytoskeleton stability at the dendritic cell immu(epmc).pdf DeepDyve Pubget Overpricing