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10.1002/eji.201444558 http://scihub22266oqcxt.onion/10.1002/eji.201444558 C5404502!5404502!26820238     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2016 ; 46 (3): 504-12 Nephropedia Template TP {{tp|p=26820238|t=2016. Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression |pdf=|usr=}}{{26820238}} gab.com Text Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26820238 #FOAvip The innate immune system represents the first line of defense during infection and is initiated by the detection of conserved microbial products by germline-encoded pattern recognition receptors (PRRs). Sensing through PRRs induces broad transcriptional changes that elicit powerful inflammatory responses. Tight regulation of these processes depends on multiple regulatory checkpoints including noncoding RNA species such as microRNAs. In addition, long noncoding RNAs (lncRNAs) have recently gained attention as important regulators of gene expression acting through versatile interactions with DNA, RNA, or proteins. As such, these RNAs have a multitude of mechanisms to modulate gene expression. Here, we summarize recent advances in this rapidly moving and evolving field, highlighting the contribution of lncRNAs to both the development and activation of innate immune cells. In addition, we discuss experimental approaches required to comprehensively investigate the function of a candidate noncoding RNA locus. Twit Text FOAVip Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26820238 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26820238 #FOAvip English Wikipedia <ref>{{Cite pmid|26820238}}</ref> Emerging role of long noncoding RNAs as regulators of innate immune cell development and inflammatory gene expression #MMPMID26820238 Elling R; Chan J; Fitzgerald KA Eur J Immunol 2016[Mar]; 46 (3): 504-12 PMID26820238show ga The innate immune system represents the first line of defense during infection and is initiated by the detection of conserved microbial products by germline-encoded pattern recognition receptors (PRRs). Sensing through PRRs induces broad transcriptional changes that elicit powerful inflammatory responses. Tight regulation of these processes depends on multiple regulatory checkpoints including noncoding RNA species such as microRNAs. In addition, long noncoding RNAs (lncRNAs) have recently gained attention as important regulators of gene expression acting through versatile interactions with DNA, RNA, or proteins. As such, these RNAs have a multitude of mechanisms to modulate gene expression. Here, we summarize recent advances in this rapidly moving and evolving field, highlighting the contribution of lncRNAs to both the development and activation of innate immune cells. In addition, we discuss experimental approaches required to comprehensively investigate the function of a candidate noncoding RNA locus. äEmerging role of long noncoding RNAs as regulators of innate immune ce(epmc).pdf DeepDyve Pubget Overpricing