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Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cell+Mol+Gastroenterol+Hepatol 2017 ; 3 (3): 331-8 Nephropedia Template TP
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The Origins of Gastric Cancer From Gastric Stem Cells: Lessons From Mouse Models #MMPMID28462375
Hayakawa Y; Fox JG; Wang TC
Cell Mol Gastroenterol Hepatol 2017[May]; 3 (3): 331-8 PMID28462375show ga
The cellular origin of digestive cancers has been a long-standing question in the cancer field. Mouse models have identified long-lived stem cells in most organ systems, including the luminal gastrointestinal tract, and numerous studies have pointed to tissue resident stem cells as the main cellular origin of cancer. During gastric carcinogenesis, chronic inflammation induces genetic and epigenetic alterations in long-lived stem cells, along with expansion of stem cell niches, eventually leading to invasive cancer. The gastric corpus and antrum have distinct stem cells and stem cell niches, suggesting differential regulation of cancer initiation at the 2 sites. In this short review, we discuss recent experimental models and human studies, which provide important insights into the pathogenesis of gastric cancer.