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10.3389/fcimb.2017.00136

http://scihub22266oqcxt.onion/10.3389/fcimb.2017.00136
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C5403948!5403948!28487845
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suck abstract from ncbi


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pmid28487845      Front+Cell+Infect+Microbiol 2017 ; 7 (ä): ä
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  • Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties #MMPMID28487845
  • Palharini JG; Richter AC; Silva MF; Ferreira FB; Pirovani CP; Naves KSC; Goulart VA; Mineo TWP; Silva MJB; Santiago FM
  • Front Cell Infect Microbiol 2017[]; 7 (ä): ä PMID28487845show ga
  • Eutirucallin is a lectin isolated from the latex of Euphorbia tirucalli, a plant known for its medical properties. The present study explores various characteristics of Eutirucallin including stability, cytotoxicity against tumor cells, antimicrobial and antiparasitic activities. Eutirucallin was stable from 2 to 40 days at 4°C, maintained hemagglutinating activity within a restricted range, and showed optimal activity at pH 7.0?8.0. Eutirucallin presented antiproliferative activity for HeLa, PC3, MDA-MB-231, and MCF-7 tumor cells but was not cytotoxic for non-tumorigenic cells such as macrophages and fibroblasts. Eutirucallin inhibited the Ehrlich ascites carcinoma in vivo and it was also observed that Eutirucallin inhibited 62.5% of Escherichia coli growth. Also, Eutirucallin showed to be effective when tested directly against Toxoplasma gondii infection in vitro. Therefore, this study sheds perspectives for pharmacological applications of Eutirucallin.
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