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10.3892/ol.2017.5651 http://scihub22266oqcxt.onion/10.3892/ol.2017.5651 C5403693!5403693!28454291     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2017 ; 13 (3): 1563-8 Nephropedia Template TP {{tp|p=28454291|t=2017. Thioridazine has potent antitumor effects on lung cancer stem-like cells |pdf=|usr=}}{{28454291}} gab.com Text Thioridazine has potent antitumor effects on lung cancer stem-like cells JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454291 #FOAvip Thioridazine (TDZ), originally an anti-psychotic drug, suppresses several types of cancer and has specificity for leukemia stem cells. The present study was performed to assess its effect on lung cancer stem-like cells, as its effect remains unknown. TDZ was utilized to treat lung cancer stem-like cells (A549 sphere cells) and its cytotoxic effect and mechanism were evaluated in vitro and in vivo. TDZ elicited cytotoxicity in A549 sphere cells and inhibited their proliferation in a dose-dependent pattern. A549 sphere cells treated with TDZ showed nuclear fragmentation, increased G0/G1 phase distribution, positive Annexin V staining, and a change in the expression of caspase family and cell cycle-associated proteins. These results suggest the induction of caspase-dependent apoptosis and cell cycle arrest. In addition, TDZ treatment resulted in significant inhibitory effect on mice xenografts established by A549 sphere cells. TDZ repressed growth of lung cancer stem-like cells in vitro and in vivo, indicating its potential application in targeting lung cancer stem-like cells. Twit Text FOAVip Thioridazine has potent antitumor effects on lung cancer stem-like cells ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454291 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28454291 #FOAvip English Wikipedia <ref>{{Cite pmid|28454291}}</ref> Thioridazine has potent antitumor effects on lung cancer stem-like cells #MMPMID28454291 Shen J; Ma B; Zhang X; Sun X; Han J; Wang Y; Chu L; Xu H; Yang Y Oncol Lett 2017[Mar]; 13 (3): 1563-8 PMID28454291show ga Thioridazine (TDZ), originally an anti-psychotic drug, suppresses several types of cancer and has specificity for leukemia stem cells. The present study was performed to assess its effect on lung cancer stem-like cells, as its effect remains unknown. TDZ was utilized to treat lung cancer stem-like cells (A549 sphere cells) and its cytotoxic effect and mechanism were evaluated in vitro and in vivo. TDZ elicited cytotoxicity in A549 sphere cells and inhibited their proliferation in a dose-dependent pattern. A549 sphere cells treated with TDZ showed nuclear fragmentation, increased G0/G1 phase distribution, positive Annexin V staining, and a change in the expression of caspase family and cell cycle-associated proteins. These results suggest the induction of caspase-dependent apoptosis and cell cycle arrest. In addition, TDZ treatment resulted in significant inhibitory effect on mice xenografts established by A549 sphere cells. TDZ repressed growth of lung cancer stem-like cells in vitro and in vivo, indicating its potential application in targeting lung cancer stem-like cells. äThioridazine has potent antitumor effects on lung cancer stem-like cel(epmc).pdf DeepDyve Pubget Overpricing