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2017 ; 27
(5
): 379-390
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From Planar Cell Polarity to Ciliogenesis and Back: The Curious Tale of the PPE
and CPLANE proteins
#MMPMID28153580
Adler PN
; Wallingford JB
Trends Cell Biol
2017[May]; 27
(5
): 379-390
PMID28153580
show ga
Why some genes are more popular than others remains an open question, but one
example of this phenomenon involves the genes controlling planar cell polarity
(PCP), the polarization of cells within a plane of a tissue. Indeed, the
so-called 'core' PCP genes such as dishevelled, frizzled, and prickle have been
extensively studied both in animal models and by human genetics. By contrast,
other genes that influence PCP signaling have received far less attention. Among
the latter are inturned, fuzzy, and fritz, but recent work should bring these
once obscure regulators into the limelight. We provide here a brief history of
planar polarity effector (PPE) and CPLANE (ciliogenesis and planar polarity
effector) proteins, discuss recent advances in understanding their molecular
mechanisms of action, and describe their roles in human disease.