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10.3892/ol.2017.5692

http://scihub22266oqcxt.onion/10.3892/ol.2017.5692
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C5403480!5403480!28454402
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suck abstract from ncbi


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pmid28454402      Oncol+Lett 2017 ; 13 (4): 2349-53
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  • miR-215 suppresses proliferation and migration of non-small cell lung cancer cells #MMPMID28454402
  • Cai X; Peng D; Wei H; Yang X; Huang Q; Lin Z; Xu W; Qian M; Yang C; Liu T; Yan W; Zhao J
  • Oncol Lett 2017[Apr]; 13 (4): 2349-53 PMID28454402show ga
  • The expression of microRNA-215 (miR-215) in non-small cell lung cancer (NSCLC) tissues and the effects of miR-215 on the proliferation and migration of NSCLC cells were investigated. qRT-PCR was used to detect the expression of miR-215 in NSCLC tissues and paired normal tumor-adjacent lung tissues; MTT assay, transwell assay and soft-agar assay were used in vitro to evaluate the role of miR-215 on proliferation, migration and cell clonality on NSCLC cells, after transfecting miR-215 mimics to NSCLC cell line A549 or miR-215 to H1299. miR-215 was significantly decreased in NSCLC tissues compared to the paired normal tissues; Overexpression of miR-215 in A549 cells resulted in reduction of the cell proliferation, migration and cell clonality, while downregulation of miR-215 in H1299 cells could promote cell proliferation, migration and clonality. In conclusion, miR-215 was downregulated in NSCLC tissues and may play a key role in the development of NSCLC.
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