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10.3892/ol.2017.5683 http://scihub22266oqcxt.onion/10.3892/ol.2017.5683 C5403445!5403445!28454421     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2017 ; 13 (4): 2465-70 Nephropedia Template TP {{tp|p=28454421|t=2017. Notch is a critical regulator in cervical cancer by regulating Numb splicing |pdf=|usr=}}{{28454421}} gab.com Text Notch is a critical regulator in cervical cancer by regulating Numb splicing JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454421 #FOAvip Cervical cancer, which is the second most common female malignancy, is characterized by the consistent presence of human papillomavirus. Inappropriate activation of Notch signaling has been associated with various types of cancer; however, the role of Notch in cervical cancer remains unclear. The present study aimed to investigate the role of Notch in cervical cancer. The methods used included the generation of plasmids, viability assays, polymerase chain reaction and western blotting The present findings demonstrated that cervical cancer samples also consistently exhibit abnormal activation of the Notch pathway. The data also indicated that different Numb isoforms may have opposite effects on the proliferation of cervical cancer cells. As a result, the activated Notch signaling pathway regulates the alternative splicing of the Numb gene, which affects the proliferation of the cervical cancer cells. These findings suggest that activated Notch signaling may lead to the development of cervical cancer by regulating Numb splicing. Thus, Numb splice variants may be a potential clinical marker for indicating cervical cancer genesis and development. Twit Text FOAVip Notch is a critical regulator in cervical cancer by regulating Numb splicing ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454421 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28454421 #FOAvip English Wikipedia <ref>{{Cite pmid|28454421}}</ref> Notch is a critical regulator in cervical cancer by regulating Numb splicing #MMPMID28454421 Rong C; Feng Y; Ye Z Oncol Lett 2017[Apr]; 13 (4): 2465-70 PMID28454421show ga Cervical cancer, which is the second most common female malignancy, is characterized by the consistent presence of human papillomavirus. Inappropriate activation of Notch signaling has been associated with various types of cancer; however, the role of Notch in cervical cancer remains unclear. The present study aimed to investigate the role of Notch in cervical cancer. The methods used included the generation of plasmids, viability assays, polymerase chain reaction and western blotting The present findings demonstrated that cervical cancer samples also consistently exhibit abnormal activation of the Notch pathway. The data also indicated that different Numb isoforms may have opposite effects on the proliferation of cervical cancer cells. As a result, the activated Notch signaling pathway regulates the alternative splicing of the Numb gene, which affects the proliferation of the cervical cancer cells. These findings suggest that activated Notch signaling may lead to the development of cervical cancer by regulating Numb splicing. Thus, Numb splice variants may be a potential clinical marker for indicating cervical cancer genesis and development. äNotch is a critical regulator in cervical cancer by regulating Numb sp(epmc).pdf DeepDyve Pubget Overpricing