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10.3892/ol.2017.5613 http://scihub22266oqcxt.onion/10.3892/ol.2017.5613 C5403440!5403440!28454293     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2017 ; 13 (3): 1575-80 Nephropedia Template TP {{tp|p=28454293|t=2017. Changes in mitochondrial function during EMT induced by TGF?-1 in pancreatic cancer |pdf=|usr=}}{{28454293}} gab.com Text Changes in mitochondrial function during EMT induced by TGF -1 in pancreatic cancer JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454293 #FOAvip Mitochondrial dysfunction is linked to cancer. Differences in the number, morphology and function of mitochondria have been observed between normal cells and cancer cells. However, changes in mitochondrial function during epithelial-mesenchymal transition (EMT) in pancreatic cancer are less known. In the present study, the cultured human pancreatic cancer cell line Panc-1 was treated with transforming growth factor (TGF)?-1. Mitochondrial functions following TGF?-1 exposure in pancreatic cancer were investigated. It was noticed that TGF?-1 treatment induces morphologic changes and a shift from epithelial to mesenchymal phenotype in pancreatic cancer. Furthermore, increased mitochondrial mass was detected in pancreatic cancer following TGF?-1 treatment. Besides, the production of reactive oxygen species in TGF?-1-treated pancreatic cancer cells significantly increased compared with the control cells. Our results indicate that the phenomenon of EMT in pancreatic cancer has an association with mitochondrial dysfunction. Mitochondrial dysfunction may be a cause of EMT in pancreatic cancer, which leads to heterogeneity in pancreatic cancer, and may be a potential therapeutic target in the future. Twit Text FOAVip Changes in mitochondrial function during EMT induced by TGF -1 in pancreatic cancer ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454293 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28454293 #FOAvip English Wikipedia <ref>{{Cite pmid|28454293}}</ref> Changes in mitochondrial function during EMT induced by TGF?-1 in pancreatic cancer #MMPMID28454293 Guo Q Oncol Lett 2017[Mar]; 13 (3): 1575-80 PMID28454293show ga Mitochondrial dysfunction is linked to cancer. Differences in the number, morphology and function of mitochondria have been observed between normal cells and cancer cells. However, changes in mitochondrial function during epithelial-mesenchymal transition (EMT) in pancreatic cancer are less known. In the present study, the cultured human pancreatic cancer cell line Panc-1 was treated with transforming growth factor (TGF)?-1. Mitochondrial functions following TGF?-1 exposure in pancreatic cancer were investigated. It was noticed that TGF?-1 treatment induces morphologic changes and a shift from epithelial to mesenchymal phenotype in pancreatic cancer. Furthermore, increased mitochondrial mass was detected in pancreatic cancer following TGF?-1 treatment. Besides, the production of reactive oxygen species in TGF?-1-treated pancreatic cancer cells significantly increased compared with the control cells. Our results indicate that the phenomenon of EMT in pancreatic cancer has an association with mitochondrial dysfunction. Mitochondrial dysfunction may be a cause of EMT in pancreatic cancer, which leads to heterogeneity in pancreatic cancer, and may be a potential therapeutic target in the future. äChanges in mitochondrial function during EMT induced by TGF?-1 in panc(epmc).pdf DeepDyve Pubget Overpricing