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10.3892/etm.2017.4052 http://scihub22266oqcxt.onion/10.3892/etm.2017.4052 C5403375!5403375!28450952     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Exp+Ther+Med 2017 ; 13 (3): 1127-32 Nephropedia Template TP {{tp|p=28450952|t=2017. MicroRNA-185 regulates spinal cord injuries induced by thoracolumbar spine compression fractures by targeting transforming growth factor-?1 |pdf=|usr=}}{{28450952}} gab.com Text MicroRNA-185 regulates spinal cord injuries induced by thoracolumbar spine compression fractures by targeting transforming growth factor- 1 JO: Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=28450952 #FOAvip The aims of the present study were to examine the expression of transforming growth factor (TGF)-?1 and microRNA (miR)-185 in the bone tissue, blood and cerebrospinal fluid of patients with spinal cord injuries and to evaluate the regulation of spinal cord injuries by miR-185. A total of 44 patients with spinal cord injuries induced by thoracolumbar spine compression fractures, who were hospitalized at Luoyang Orthopedic-Traumatological Hospital between June 2012 and February 2015 were enrolled in the present study. Among the patients enrolled, 18 underwent surgery between 1 and 7 days following fracture, and 26 patients underwent surgery between 8 and 14 days following fracture. Bone tissue, peripheral blood and cerebrospinal fluid were subsequently harvested from patients for analysis. Reverse transcription-quantitative polymerase chain reaction was performed to determine the expression of miR-185 and TGF-?1 mRNA. Western blotting was performed to evaluate TGF-?1 protein expression in bone tissue and ELISA was employed to quantify TGF-?1 protein expression in the blood and cerebrospinal fluid. TGF-?1 mRNA and protein levels in bone tissue, blood and cerebrospinal fluid from patients who underwent surgery 8?14 days post-fracture were significantly higher than those who underwent surgery 1?7 days post-fracture (P<0.05). By contrast, miR-185 levels were significantly lower in bone tissue, blood and cerebrospinal fluid from patients who underwent surgery 8?14 days post-fracture compared with those who underwent surgery 1?7 days post-fracture (P<0.05). The results of the present study desmonstrate that the upregulation of TGF-?1 in the bone tissue, blood and cerebrospinal fluid of patients with spinal cord injuries induced by thoracolumbar spine compression fractures is correlated with the downregulation of miR-185. Furthermore, miR-185 may target TGF-?1, affecting its transcription and translation, indicating that it serves an important role in spinal cord injuries induced by thoracolumbar spine compression fractures. Twit Text FOAVip MicroRNA-185 regulates spinal cord injuries induced by thoracolumbar spine compression fractures by targeting transforming growth factor- 1 ????Exp Ther Med http://www.kidney.de/pget.php?&tw=1&pmid=28450952 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28450952 #FOAvip English Wikipedia <ref>{{Cite pmid|28450952}}</ref> MicroRNA-185 regulates spinal cord injuries induced by thoracolumbar spine compression fractures by targeting transforming growth factor-?1 #MMPMID28450952 Zhao P; Wang S; Zhou Y; Zheng H; Zhao G Exp Ther Med 2017[Mar]; 13 (3): 1127-32 PMID28450952show ga The aims of the present study were to examine the expression of transforming growth factor (TGF)-?1 and microRNA (miR)-185 in the bone tissue, blood and cerebrospinal fluid of patients with spinal cord injuries and to evaluate the regulation of spinal cord injuries by miR-185. A total of 44 patients with spinal cord injuries induced by thoracolumbar spine compression fractures, who were hospitalized at Luoyang Orthopedic-Traumatological Hospital between June 2012 and February 2015 were enrolled in the present study. Among the patients enrolled, 18 underwent surgery between 1 and 7 days following fracture, and 26 patients underwent surgery between 8 and 14 days following fracture. Bone tissue, peripheral blood and cerebrospinal fluid were subsequently harvested from patients for analysis. Reverse transcription-quantitative polymerase chain reaction was performed to determine the expression of miR-185 and TGF-?1 mRNA. Western blotting was performed to evaluate TGF-?1 protein expression in bone tissue and ELISA was employed to quantify TGF-?1 protein expression in the blood and cerebrospinal fluid. TGF-?1 mRNA and protein levels in bone tissue, blood and cerebrospinal fluid from patients who underwent surgery 8?14 days post-fracture were significantly higher than those who underwent surgery 1?7 days post-fracture (P<0.05). By contrast, miR-185 levels were significantly lower in bone tissue, blood and cerebrospinal fluid from patients who underwent surgery 8?14 days post-fracture compared with those who underwent surgery 1?7 days post-fracture (P<0.05). The results of the present study desmonstrate that the upregulation of TGF-?1 in the bone tissue, blood and cerebrospinal fluid of patients with spinal cord injuries induced by thoracolumbar spine compression fractures is correlated with the downregulation of miR-185. Furthermore, miR-185 may target TGF-?1, affecting its transcription and translation, indicating that it serves an important role in spinal cord injuries induced by thoracolumbar spine compression fractures. äMicroRNA-185 regulates spinal cord injuries induced by thoracolumbar s(epmc).pdf DeepDyve Pubget Overpricing