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10.3892/ol.2017.5563 http://scihub22266oqcxt.onion/10.3892/ol.2017.5563 C5403332!5403332!28454273     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2017 ; 13 (3): 1432-6 Nephropedia Template TP {{tp|p=28454273|t=2017. Repurposing cimetidine for cholangiocarcinoma: Antitumor effects in vitro and in vivo |pdf=|usr=}}{{28454273}} gab.com Text Repurposing cimetidine for cholangiocarcinoma: Antitumor effects in vitro and in vivo JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454273 #FOAvip Cimetidine is a histamine type-2 (H2) receptor antagonist that has been demonstrated to have antitumor effects on various types of malignancy. However, its effect on cholangiocarcinoma (CCA), a chemotherapy-resistant bile duct tumor, has yet to be investigated. In the present study, the antitumor activity of cimetidine in vitro and in vivo was evaluated. A methylthiotetrazole assay revealed that the proliferation of certain CCA cell lines was inhibited by cimetidine, which induced the caspase-dependent apoptosis of CCA cells via suppression of the protein kinase B signaling pathway. Suppression of Akt phosphorylation, caspase-3, ?8 and ?9 activation, phosphotidylserine exposure determined by Annexin V binding assay and the presence of a sub-G1 population were demonstrated by western blotting and flow cytometry analysis. In a CCA xenograft mouse model cimetidine inhibited the growth of CCA cells without observable adverse effects. These results suggest that cimetidine has the potential to be an effective antitumor agent for the treatment of CCA. Twit Text FOAVip Repurposing cimetidine for cholangiocarcinoma: Antitumor effects in vitro and in vivo ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454273 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28454273 #FOAvip English Wikipedia <ref>{{Cite pmid|28454273}}</ref> Repurposing cimetidine for cholangiocarcinoma: Antitumor effects in vitro and in vivo #MMPMID28454273 Dana P; Vaeteewoottacharn K; Kariya R; Matsuda K; Wongkham S; Okada S Oncol Lett 2017[Mar]; 13 (3): 1432-6 PMID28454273show ga Cimetidine is a histamine type-2 (H2) receptor antagonist that has been demonstrated to have antitumor effects on various types of malignancy. However, its effect on cholangiocarcinoma (CCA), a chemotherapy-resistant bile duct tumor, has yet to be investigated. In the present study, the antitumor activity of cimetidine in vitro and in vivo was evaluated. A methylthiotetrazole assay revealed that the proliferation of certain CCA cell lines was inhibited by cimetidine, which induced the caspase-dependent apoptosis of CCA cells via suppression of the protein kinase B signaling pathway. Suppression of Akt phosphorylation, caspase-3, ?8 and ?9 activation, phosphotidylserine exposure determined by Annexin V binding assay and the presence of a sub-G1 population were demonstrated by western blotting and flow cytometry analysis. In a CCA xenograft mouse model cimetidine inhibited the growth of CCA cells without observable adverse effects. These results suggest that cimetidine has the potential to be an effective antitumor agent for the treatment of CCA. äRepurposing cimetidine for cholangiocarcinoma: Antitumor effects in vi(epmc).pdf DeepDyve Pubget Overpricing