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10.3892/ol.2017.5604 http://scihub22266oqcxt.onion/10.3892/ol.2017.5604 C5403329!5403329!28454326     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncol+Lett 2017 ; 13 (3): 1797-806 Nephropedia Template TP {{tp|p=28454326|t=2017. TRIM24 promotes the aggression of gastric cancer via the Wnt/?-catenin signaling pathway |pdf=|usr=}}{{28454326}} gab.com Text TRIM24 promotes the aggression of gastric cancer via the Wnt/ -catenin signaling pathway JO: Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454326 #FOAvip Tripartite motif-containing 24 (TRIM24) is important in tumor development and progression. However, the role of TRIM24 in gastric cancer (GC) and the mechanisms underlying the dysregulated expression of TRIM24 remain to be fully elucidated. In the present study, it was found that TRIM24 was frequently overexpressed in GC cell lines and tissues compared with normal controls, as determined by western blotting and immunohistochemical staining. The high nuclear expression of TRIM24 was correlated with the depth of invasion (P=0.007), tumor-node-metastasis stage (P=0.005), and lymph node metastasis (P=0.027), and shorter overall survival rates (P=0.010) in patients with GC. Small interfering RNA-mediated knockdown of TRIM24 inhibited cell proliferation, colony formation, migration, invasion and the nuclear accumulation of ?-catenin, and it delayed cell cycle progression and induced apoptosis. In addition, the expression of TRIM24 was positively correlated with that of ?-catenin in GC tissues. TRIM24 knockdown decreased the expression of Wnt/?-catenin target genes, whereas the activation of Wnt/?-catenin signaling by lithium chloride reversed the effects of TRIM24 knockdown. Taken together, these data suggested that TRIM24 was a prognostic or potential therapeutic target for patients with GC and was important in the activation of the Wnt/?-catenin pathway during the progression of GC. Twit Text FOAVip TRIM24 promotes the aggression of gastric cancer via the Wnt/ -catenin signaling pathway ????Oncol Lett http://www.kidney.de/pget.php?&tw=1&pmid=28454326 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28454326 #FOAvip English Wikipedia <ref>{{Cite pmid|28454326}}</ref> TRIM24 promotes the aggression of gastric cancer via the Wnt/?-catenin signaling pathway #MMPMID28454326 Fang Z; Deng J; Zhang L; Xiang X; Yu F; Chen J; Feng M; Xiong J Oncol Lett 2017[Mar]; 13 (3): 1797-806 PMID28454326show ga Tripartite motif-containing 24 (TRIM24) is important in tumor development and progression. However, the role of TRIM24 in gastric cancer (GC) and the mechanisms underlying the dysregulated expression of TRIM24 remain to be fully elucidated. In the present study, it was found that TRIM24 was frequently overexpressed in GC cell lines and tissues compared with normal controls, as determined by western blotting and immunohistochemical staining. The high nuclear expression of TRIM24 was correlated with the depth of invasion (P=0.007), tumor-node-metastasis stage (P=0.005), and lymph node metastasis (P=0.027), and shorter overall survival rates (P=0.010) in patients with GC. Small interfering RNA-mediated knockdown of TRIM24 inhibited cell proliferation, colony formation, migration, invasion and the nuclear accumulation of ?-catenin, and it delayed cell cycle progression and induced apoptosis. In addition, the expression of TRIM24 was positively correlated with that of ?-catenin in GC tissues. TRIM24 knockdown decreased the expression of Wnt/?-catenin target genes, whereas the activation of Wnt/?-catenin signaling by lithium chloride reversed the effects of TRIM24 knockdown. Taken together, these data suggested that TRIM24 was a prognostic or potential therapeutic target for patients with GC and was important in the activation of the Wnt/?-catenin pathway during the progression of GC. äTRIM24 promotes the aggression of gastric cancer via the Wnt/?-catenin(epmc).pdf DeepDyve Pubget Overpricing