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2017 ; 13
(4
): 2015-2020
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Harnessing antitumor immunity: Employment of tumor recall antigens to optimize
the inflammatory response to cancer
#MMPMID28454356
Silverio KA
; Patel SA
Oncol Lett
2017[Apr]; 13
(4
): 2015-2020
PMID28454356
show ga
The advent of immunotherapy for cancer has contributed to the era of personalized
medicine for cancer. The various immunotherapy-based treatments that have been
explored thus far include monoclonal antibody therapy, tumor vaccines, immune
checkpoint blockade and adoptive T cell transfer, among others. The groundwork
for all these immunotherapeutic modalities rests within the tumor
microenvironment, specifically the immune factors that influence the tumor-drug
interface. Prior to therapeutic design, the tumor microenvironmental interactions
and the current barriers to successful treatment must first be understood. In the
present review, it is proposed that cancer cell eradication within the tumor
niche may be achieved by reprogramming of the immune microenvironment in favor of
a pro-inflammatory antitumor profile at an early stage. This pro-inflammatory
profile may, in turn, be influenced by tumor recall antigens, which function to
stimulate the cell-mediated or humoral responses involved in antitumor immunity.
These measures serve to counteract the immunotolerant state of the tumor
microenvironment. Such measures are critical to therapeutic successes.