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10.1016/j.trecan.2017.03.002

http://scihub22266oqcxt.onion/10.1016/j.trecan.2017.03.002
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C5402749!5402749!28451648
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suck abstract from ncbi

pmid28451648      Trends+Cancer 2017 ; 3 (4): 294-301
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  • Necroptosis and Cancer #MMPMID28451648
  • Najafov A; Chen H; Yuan J
  • Trends Cancer 2017[Apr]; 3 (4): 294-301 PMID28451648show ga
  • Necroptosis is a programmed lytic cell death pathway, deregulation of which is linked to various inflammatory disorders. Escape from programmed cell death and inflammation play a significant role in cancer, and therefore, investigating the role of necroptosis in cancer has been of high interest. Necroptosis has been shown to promote cancer metastasis and T cells death. Escape from necroptosis via loss of RIPK3 expression is a feature of some cancers. While necroptosis is a promising novel target for cancer therapies, further investigation into its biological role in carcinogenesis is warranted. In this article, we review the recently-identified interplay points between necroptosis and cancer, and outline major biological questions that require further inquiry on the road to targeting this pathway in cancer.
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