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10.1016/j.stem.2016.07.004 http://scihub22266oqcxt.onion/10.1016/j.stem.2016.07.004 C5402355!5402355!27524439     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Stem+Cell 2016 ; 19 (4): 530-43 Nephropedia Template TP {{tp|p=27524439|t=2016. Proximity-based differential single cell analysis of the niche to identify stem/progenitor cell regulators |pdf=|usr=}}{{27524439}} gab.com Text Proximity-based differential single cell analysis of the niche to identify stem/progenitor cell regulators JO: Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27524439 #FOAvip Physiological stem cell function is regulated by secreted factors produced by niche cells. In this study, we describe an unbiased approach based on differential single-cell gene expression analysis of mesenchymal osteolineage cells close to and further removed from hematopoietic stem/progenitor cells to identify candidate niche factors. Mesenchymal cells displayed distinct molecular profiles based on their relative location. Amongst the genes which were preferentially expressed in proximal cells, we functionally examined three secreted or cell surface molecules not previously connected to HSPC biology: the secreted RNase Angiogenin, the cytokine IL18 and the adhesion molecule Embigin and discovered that all of these factors are HSPC quiescence regulators. Our proximity-based differential single cell approach therefore reveals molecular heterogeneity within niche cells and can be used to identify novel extrinsic stem/progenitor cell regulators. Similar approaches could also be applied to other stem cell/niche pairs to advance understanding of microenvironmental regulation of stem cell function. Twit Text FOAVip Proximity-based differential single cell analysis of the niche to identify stem/progenitor cell regulators ????Cell Stem Cell http://www.kidney.de/pget.php?&tw=1&pmid=27524439 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27524439 #FOAvip English Wikipedia <ref>{{Cite pmid|27524439}}</ref> Proximity-based differential single cell analysis of the niche to identify stem/progenitor cell regulators #MMPMID27524439 Silberstein L; Goncalves KA; Kharchenko PV; Turcotte R; Kfoury Y; Mercier F; Baryawno N; Severe N; Bachand J; Spencer J; Papazian A; Lee D; Chitteti BR; Srour EF; Hoggatt J; Tate T; Celso CL; Ono N; Nutt S; Heino J; Sipilä K; Shioda T; Osawa M; Lin CP; Hu Gf; Scadden DT Cell Stem Cell 2016[Oct]; 19 (4): 530-43 PMID27524439show ga Physiological stem cell function is regulated by secreted factors produced by niche cells. In this study, we describe an unbiased approach based on differential single-cell gene expression analysis of mesenchymal osteolineage cells close to and further removed from hematopoietic stem/progenitor cells to identify candidate niche factors. Mesenchymal cells displayed distinct molecular profiles based on their relative location. Amongst the genes which were preferentially expressed in proximal cells, we functionally examined three secreted or cell surface molecules not previously connected to HSPC biology: the secreted RNase Angiogenin, the cytokine IL18 and the adhesion molecule Embigin and discovered that all of these factors are HSPC quiescence regulators. Our proximity-based differential single cell approach therefore reveals molecular heterogeneity within niche cells and can be used to identify novel extrinsic stem/progenitor cell regulators. Similar approaches could also be applied to other stem cell/niche pairs to advance understanding of microenvironmental regulation of stem cell function. äProximity-based differential single cell analysis of the niche to iden(epmc).pdf DeepDyve Pubget Overpricing