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10.1016/j.taap.2016.06.001 http://scihub22266oqcxt.onion/10.1016/j.taap.2016.06.001 C5402341!5402341!27282297     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Appl+Pharmacol 2016 ; 305 (ä): 143-52 Nephropedia Template TP {{tp|p=27282297|t=2016. Mobilization and removing of cadmium from kidney by GMDTC utilizing renal glucose reabsorption pathway |pdf=|usr=}}{{27282297}} gab.com Text Mobilization and removing of cadmium from kidney by GMDTC utilizing renal glucose reabsorption pathway JO: Toxicol Appl Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27282297 #FOAvip Chronic exposure to cadmium compounds (Cd2+) is one of the major public health problems facing humans in the 21st century. Cd2+ in the human body accumulates primarily in the kidneys which leads to renal dysfunction and other adverse health effects. Efforts to find a safe and effective drug for removing Cd2+ from the kidneys have largely failed. We developed and synthesized a new chemical, sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6 pentahydroxyhexyl)amino)-4-(methylthio) butanoate (GMDTC). Here we report that GMDTC has a very low toxicity with an acute lethal dose (LD50) of more than 10,000 mg/kg or 5000 mg/kg body weight, respectively, via oral or intraperitoneal injection in mice and rats. In in vivo settings, up to 94% of Cd2+ deposited in the kidneys of Cd2+-laden rabbits was removed and excreted via urine following a safe dose of GMDTC treatment for four weeks, and renal Cd2+ level was reduced from 12.9 ?g/g to 1.3 ?g/g kidney weight. We observed similar results in the mouse and rat studies. Further, we demonstrated both in in vitro and in animal studies that the mechanism of transporting GMDTC and GMDTC-Cd complex into and out of renal tubular cells is likely assisted by two glucose transporters, sodium glucose cotransporter 2 (SGLT2) and glucose transporter 2 (GLUT2). Collectively, our study reports that GMDTC is safe and highly efficient in removing deposited Cd2+ from kidneys assisted by renal glucose reabsorption system, suggesting that GMDTC may be the long-pursued agent used for preventive and therapeutic purposes for both acute and chronic Cd2+ exposure. Twit Text FOAVip Mobilization and removing of cadmium from kidney by GMDTC utilizing renal glucose reabsorption pathway ????Toxicol Appl Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=27282297 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27282297 #FOAvip English Wikipedia <ref>{{Cite pmid|27282297}}</ref> Mobilization and removing of cadmium from kidney by GMDTC utilizing renal glucose reabsorption pathway #MMPMID27282297 Tang X; Zhu J; Zhong Z; Luo M; Li G; Gong Z; Zhang C; Fei F; Ruan X; Zhou J; Liu G; Li G; Olson J; Ren X Toxicol Appl Pharmacol 2016[Aug]; 305 (ä): 143-52 PMID27282297show ga Chronic exposure to cadmium compounds (Cd2+) is one of the major public health problems facing humans in the 21st century. Cd2+ in the human body accumulates primarily in the kidneys which leads to renal dysfunction and other adverse health effects. Efforts to find a safe and effective drug for removing Cd2+ from the kidneys have largely failed. We developed and synthesized a new chemical, sodium (S)-2-(dithiocarboxylato((2S,3R,4R,5R)-2,3,4,5,6 pentahydroxyhexyl)amino)-4-(methylthio) butanoate (GMDTC). Here we report that GMDTC has a very low toxicity with an acute lethal dose (LD50) of more than 10,000 mg/kg or 5000 mg/kg body weight, respectively, via oral or intraperitoneal injection in mice and rats. In in vivo settings, up to 94% of Cd2+ deposited in the kidneys of Cd2+-laden rabbits was removed and excreted via urine following a safe dose of GMDTC treatment for four weeks, and renal Cd2+ level was reduced from 12.9 ?g/g to 1.3 ?g/g kidney weight. We observed similar results in the mouse and rat studies. Further, we demonstrated both in in vitro and in animal studies that the mechanism of transporting GMDTC and GMDTC-Cd complex into and out of renal tubular cells is likely assisted by two glucose transporters, sodium glucose cotransporter 2 (SGLT2) and glucose transporter 2 (GLUT2). Collectively, our study reports that GMDTC is safe and highly efficient in removing deposited Cd2+ from kidneys assisted by renal glucose reabsorption system, suggesting that GMDTC may be the long-pursued agent used for preventive and therapeutic purposes for both acute and chronic Cd2+ exposure. äMobilization and removing of cadmium from kidney by GMDTC utilizing re(epmc).pdf DeepDyve Pubget Overpricing