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10.1038/srep46687 http://scihub22266oqcxt.onion/10.1038/srep46687 C5402289!5402289 !28436478     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28436478 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (ä): 46687 Nephropedia Template TP {{tp|p=28436478 |t=2017. Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure |pdf=|usr=}}{{28436478 }} gab.com Text Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28436478 #FOAvip Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and pristine polystyrene microplastics (PS-MPs) particles with two diameters (5??m and 20??m) to investigate the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice. Results indicated that MPs accumulated in liver, kidney and gut, with a tissue-accumulation kinetics and distribution pattern that was strongly depended on the MPs particle size. In addition, analyses of multiple biochemical biomarkers and metabolomic profiles suggested that MPs exposure induced disturbance of energy and lipid metabolism as well as oxidative stress. Interestingly, blood biomarkers of neurotoxicity were also altered. Our results uncovered the distribution and accumulation of MPs across mice tissues and revealed significant alteration in several biomarkers that indicate potential toxicity from MPs exposure. Collectively, our data provided new evidence for the adverse consequences of MPs. Twit Text FOAVip Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28436478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28436478 #FOAvip English Wikipedia <ref>{{Cite pmid|28436478 }}</ref> Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure #MMPMID28436478 Deng Y ; Zhang Y ; Lemos B ; Ren H Sci Rep 2017[Apr]; 7 (ä): 46687 PMID28436478 show ga Microplastics (MPs) are a significant environmental health issue and increasingly greater source of concern. MPs have been detected in oceans, rivers, sediments, sewages, soil and even table salts. MPs exposure on marine organisms and humans has been documented, but information about the toxicity of MPs in mammal is limited. Here we used fluorescent and pristine polystyrene microplastics (PS-MPs) particles with two diameters (5??m and 20??m) to investigate the tissue distribution, accumulation, and tissue-specific health risk of MPs in mice. Results indicated that MPs accumulated in liver, kidney and gut, with a tissue-accumulation kinetics and distribution pattern that was strongly depended on the MPs particle size. In addition, analyses of multiple biochemical biomarkers and metabolomic profiles suggested that MPs exposure induced disturbance of energy and lipid metabolism as well as oxidative stress. Interestingly, blood biomarkers of neurotoxicity were also altered. Our results uncovered the distribution and accumulation of MPs across mice tissues and revealed significant alteration in several biomarkers that indicate potential toxicity from MPs exposure. Collectively, our data provided new evidence for the adverse consequences of MPs. |Animals [MESH] |Biomarkers/blood/*metabolism [MESH] |Environmental Exposure/adverse effects/*analysis [MESH] |Gastrointestinal Tract/metabolism [MESH] |Kidney/metabolism [MESH] |Liver/metabolism [MESH] |Male [MESH] |Metabolomics/methods [MESH] |Mice, Inbred ICR [MESH] |Particle Size [MESH] |Polystyrenes/chemistry/*metabolism/pharmacokinetics [MESH] |Risk Factors [MESH] |Tissue Distribution [MESH]Tissue accumulation of microplastics in mice and biomarker responses s(epmc).pdf DeepDyve Pubget Overpricing