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2017 ; 8
(2
): 293-301
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Biliary cancer: intrahepatic cholangiocarcinoma vs extrahepatic
cholangiocarcinoma vs gallbladder cancers: classification and therapeutic
implications
#MMPMID28480068
Ahn DH
; Bekaii-Saab T
J Gastrointest Oncol
2017[Apr]; 8
(2
): 293-301
PMID28480068
show ga
Biliary cancers (BCs) are a diverse group of tumors that arise from the bile duct
epithelium and are divided into cholangiocarcinomas of the intrahepatic and
extrahepatic cholangiocarcinoma (EHCC) and cancer of the gallbladder. Despite
improvements in treatment and diagnosis, BCs are often diagnosed at an advanced
stage and associated with poor prognosis and limited treatment options. Recent
discoveries have allowed us to have a better understanding of the genomic
diversity in BC, and identify genes that are likely contributing to its
pathogenesis, proliferation and treatment resistance. Additionally, these
advances have allowed us to reason that each anatomic group within BC behave as
distinct diseases, with differences in prognosis and outcomes. Based on this
knowledge, recent advances have allowed us to identify actionable mutations that
form rational therapeutic targets with novel agents, where their relevance will
be better understood through the completion of prospective clinical trials.