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10.1186/s13052-017-0360-1 http://scihub22266oqcxt.onion/10.1186/s13052-017-0360-1 C5401564!5401564 !28431585     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28431585 &cmd=llinks): Failed to open stream: HTTP request failed! 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The utility of the basophil activation test in the diagnosis of immediate amoxicillin or amoxicillin-clavulanate hypersensitivity in children and adults |pdf=|usr=}}{{28431585 }} gab.com Text The utility of the basophil activation test in the diagnosis of immediate amoxicillin or amoxicillin-clavulanate hypersensitivity in children and adults JO: Ital J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=28431585 #FOAvip BACKGROUND: The basophil activation test (BAT), has been proposed as a possible assay for the diagnosis of immediate-type allergy to beta-lactams (BLs). The aim of this study was to assess the utility of BAT in the diagnosis of amoxicillin (AMX) or AMX-clavulanate (AMX-C) IgE-mediated hypersensitivity in children and adults. MATERIAL AND METHODS: Eighteen children and 21 adults, with clinical history of immediate reactions to AMX or AMX-C, were referred to Anna Meyer Children's Hospital and San Giovanni di Dio Hospital, respectively. They underwent in vivo tests (skin prick test and intradermal test). Moreover, BAT with AMX or AMX-C was performed within 6 months from the reaction. RESULTS: In the pediatric group, the concordance between the skin tests (ST) and BAT results was 83.3%. Upon comparing the symptom grades and ST results to the BAT results, we found that the reaction severity and ST positivity did not correlate with BAT results in children. In the adult group, the concordance between the ST and BAT results was 61.9%. Upon comparing patients with severe reactions and patients with mild reactions in terms of BAT results, we found a BAT sensitivity of 38.5% and a specificity of 100%. When comparing the symptom grades to the BAT results, we found that no patients with mild symptoms had a positive BAT result, whereas 38.5% of patients with severe symptoms had a positive BAT result. CONCLUSIONS: BAT does not seem to be a useful tool to increase the sensitivity of an allergy work-up to diagnose immediate hypersensitivity to AMX or AMX-C. Twit Text FOAVip The utility of the basophil activation test in the diagnosis of immediate amoxicillin or amoxicillin-clavulanate hypersensitivity in children and adults ????Ital J Pediatr http://www.kidney.de/pget.php?&tw=1&pmid=28431585 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28431585 #FOAvip English Wikipedia <ref>{{Cite pmid|28431585 }}</ref> The utility of the basophil activation test in the diagnosis of immediate amoxicillin or amoxicillin-clavulanate hypersensitivity in children and adults #MMPMID28431585 Barni S ; Mori F ; Valleriani C ; Mangone G ; Testi S ; Saretta F ; Sarti L ; Pucci N ; de Martino M ; Azzari C ; Novembre E Ital J Pediatr 2017[Apr]; 43 (1 ): 42 PMID28431585 show ga BACKGROUND: The basophil activation test (BAT), has been proposed as a possible assay for the diagnosis of immediate-type allergy to beta-lactams (BLs). The aim of this study was to assess the utility of BAT in the diagnosis of amoxicillin (AMX) or AMX-clavulanate (AMX-C) IgE-mediated hypersensitivity in children and adults. MATERIAL AND METHODS: Eighteen children and 21 adults, with clinical history of immediate reactions to AMX or AMX-C, were referred to Anna Meyer Children's Hospital and San Giovanni di Dio Hospital, respectively. They underwent in vivo tests (skin prick test and intradermal test). Moreover, BAT with AMX or AMX-C was performed within 6 months from the reaction. RESULTS: In the pediatric group, the concordance between the skin tests (ST) and BAT results was 83.3%. Upon comparing the symptom grades and ST results to the BAT results, we found that the reaction severity and ST positivity did not correlate with BAT results in children. In the adult group, the concordance between the ST and BAT results was 61.9%. Upon comparing patients with severe reactions and patients with mild reactions in terms of BAT results, we found a BAT sensitivity of 38.5% and a specificity of 100%. When comparing the symptom grades to the BAT results, we found that no patients with mild symptoms had a positive BAT result, whereas 38.5% of patients with severe symptoms had a positive BAT result. CONCLUSIONS: BAT does not seem to be a useful tool to increase the sensitivity of an allergy work-up to diagnose immediate hypersensitivity to AMX or AMX-C. |Adolescent [MESH] |Adult [MESH] |Age Factors [MESH] |Amoxicillin-Potassium Clavulanate Combination/administration & dosage/*immunology [MESH] |Amoxicillin/administration & dosage/*immunology [MESH] |Basophils/*drug effects/immunology [MESH] |Child [MESH] |Child, Preschool [MESH] |Cohort Studies [MESH] |Databases, Factual [MESH] |Drug Hypersensitivity/*diagnosis/immunology [MESH] |Female [MESH] |Humans [MESH] |Hypersensitivity, Immediate/*diagnosis/immunology [MESH] |Immunologic Tests/methods [MESH] |Male [MESH] |Retrospective Studies [MESH] |Risk Assessment [MESH] |Sensitivity and Specificity [MESH]The utility of the basophil activation test in the diagnosis of immedi(epmc).pdf DeepDyve Pubget Overpricing