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10.18632/oncotarget.15670 http://scihub22266oqcxt.onion/10.18632/oncotarget.15670 C5400631!5400631!28423533     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (13): 21884-91 Nephropedia Template TP {{tp|p=28423533|t=2017. SPC24 is critical for anaplastic thyroid cancer progression |pdf=|usr=}}{{28423533}} gab.com Text SPC24 is critical for anaplastic thyroid cancer progression JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28423533 #FOAvip In the past 2 decades, the incidence of thyroid cancer has been rapidly increasing worldwide. Anaplastic thyroid cancer (ATC) is the most lethal of all thyroid cancers and one of the most aggressive human carcinomas. SPC24 is an important component of the mitotic checkpoint machinery in the tumorigenesis and high levels of SPC24 have been found in colorectal and hepatocellular carcinomas, but its role in anaplastic thyroid cancer is still unclear. Our results showed that SPC24 was high expressed in human thyroid cancer samples. In addition, knockingdown endogenous SPC24 could repress cell growth, inhibit cell invasive ability and promote apoptosis in different ATC cells. Next, in vivo xenograft studies indicated that the SPC24 knockdown cells has decreased tumor size compared to the controls. This conclusion is also endorsed by our studies using human thyroid cancer samples. Taken together, our data demonstrates that SPC24 can serve as a promising prognostic biomarker of ATC cells and it is a novel strategy which could be developed by targeting SPC24 in future. Twit Text FOAVip SPC24 is critical for anaplastic thyroid cancer progression ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28423533 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28423533 #FOAvip English Wikipedia <ref>{{Cite pmid|28423533}}</ref> SPC24 is critical for anaplastic thyroid cancer progression #MMPMID28423533 Yin H; Meng T; Zhou L; Chen H; Song D Oncotarget 2017[Mar]; 8 (13): 21884-91 PMID28423533show ga In the past 2 decades, the incidence of thyroid cancer has been rapidly increasing worldwide. Anaplastic thyroid cancer (ATC) is the most lethal of all thyroid cancers and one of the most aggressive human carcinomas. SPC24 is an important component of the mitotic checkpoint machinery in the tumorigenesis and high levels of SPC24 have been found in colorectal and hepatocellular carcinomas, but its role in anaplastic thyroid cancer is still unclear. Our results showed that SPC24 was high expressed in human thyroid cancer samples. In addition, knockingdown endogenous SPC24 could repress cell growth, inhibit cell invasive ability and promote apoptosis in different ATC cells. Next, in vivo xenograft studies indicated that the SPC24 knockdown cells has decreased tumor size compared to the controls. This conclusion is also endorsed by our studies using human thyroid cancer samples. Taken together, our data demonstrates that SPC24 can serve as a promising prognostic biomarker of ATC cells and it is a novel strategy which could be developed by targeting SPC24 in future. äSPC24 is critical for anaplastic thyroid cancer progression (epmc).pdf DeepDyve Pubget Overpricing