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10.18632/oncotarget.15232 http://scihub22266oqcxt.onion/10.18632/oncotarget.15232 C5400592!5400592 !28423485     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28423485 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (13 ): 21398-21409 Nephropedia Template TP {{tp|p=28423485 |t=2017. M2 polarization of macrophages facilitates arsenic-induced cell transformation of lung epithelial cells |pdf=|usr=}}{{28423485 }} gab.com Text M2 polarization of macrophages facilitates arsenic-induced cell transformation of lung epithelial cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28423485 #FOAvip The alterations in microenvironment upon chronic arsenic exposure may contribute to arsenic-induced lung carcinogenesis. Immune cells, such as macrophages, play an important role in mediating the microenvironment in the lungs. Macrophages carry out their functions after activation. There are two activation status for macrophages: classical (M1) or alternative (M2); the latter is associated with tumorigenesis. Our previous work showed that long-term arsenic exposure induces transformation of lung epithelial cells. However, the crosstalk between epithelial cells and macrophages upon arsenic exposure has not been investigated. In this study, using a co-culture system in which human lung epithelial cells are cultured with macrophages, we determined that long-term arsenic exposure polarizes macrophages towards M2 status through ROS generation. Co-culture with epithelial cells further enhanced the polarization of macrophages as well as transformation of epithelial cells, while blocking macrophage M2 polarization decreased the transformation. In addition, macrophage M2 polarization decreased autophagy activity, which may account for increased cell transformation of epithelial cells with co-culture of macrophages. Twit Text FOAVip M2 polarization of macrophages facilitates arsenic-induced cell transformation of lung epithelial cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28423485 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28423485 #FOAvip English Wikipedia <ref>{{Cite pmid|28423485 }}</ref> M2 polarization of macrophages facilitates arsenic-induced cell transformation of lung epithelial cells #MMPMID28423485 Cui J ; Xu W ; Chen J ; Li H ; Dai L ; Frank JA ; Peng S ; Wang S ; Chen G Oncotarget 2017[Mar]; 8 (13 ): 21398-21409 PMID28423485 show ga The alterations in microenvironment upon chronic arsenic exposure may contribute to arsenic-induced lung carcinogenesis. Immune cells, such as macrophages, play an important role in mediating the microenvironment in the lungs. Macrophages carry out their functions after activation. There are two activation status for macrophages: classical (M1) or alternative (M2); the latter is associated with tumorigenesis. Our previous work showed that long-term arsenic exposure induces transformation of lung epithelial cells. However, the crosstalk between epithelial cells and macrophages upon arsenic exposure has not been investigated. In this study, using a co-culture system in which human lung epithelial cells are cultured with macrophages, we determined that long-term arsenic exposure polarizes macrophages towards M2 status through ROS generation. Co-culture with epithelial cells further enhanced the polarization of macrophages as well as transformation of epithelial cells, while blocking macrophage M2 polarization decreased the transformation. In addition, macrophage M2 polarization decreased autophagy activity, which may account for increased cell transformation of epithelial cells with co-culture of macrophages. |Arsenic/*toxicity [MESH] |Blotting, Western [MESH] |Cell Differentiation/drug effects/immunology [MESH] |Cell Transformation, Neoplastic/*chemically induced/drug effects [MESH] |Cells, Cultured [MESH] |Coculture Techniques [MESH] |Flow Cytometry [MESH] |Humans [MESH] |Lung Neoplasms/chemically induced [MESH] |Macrophage Activation/*immunology [MESH] |Real-Time Polymerase Chain Reaction [MESH]M2 polarization of macrophages facilitates arsenic-induced cell transf(epmc).pdf DeepDyve Pubget Overpricing