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10.18632/oncotarget.15343 http://scihub22266oqcxt.onion/10.18632/oncotarget.15343 C5400547!5400547!28209915     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Oncotarget 2017 ; 8 (13): 20813-24 Nephropedia Template TP {{tp|p=28209915|t=2017. Exclusive destruction of mitotic spindles in human cancer cells |pdf=|usr=}}{{28209915}} gab.com Text Exclusive destruction of mitotic spindles in human cancer cells JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28209915 #FOAvip We identified target proteins modified by phenanthrenes that cause exclusive eradication of human cancer cells. The cytotoxic activity of the phenanthrenes in a variety of human cancer cells is attributed by these findings to post translational modifications of NuMA and kinesins HSET/kifC1 and kif18A. Their activity prevented the binding of NuMA to ?-tubulin and kinesins in human cancer cells, and caused aberrant spindles. The most efficient cytotoxic activity of the phenanthridine PJ34, caused significantly smaller aberrant spindles with disrupted spindle poles and scattered extra-centrosomes and chromosomes. Concomitantly, PJ34 induced tumor growth arrest of human malignant tumors developed in athymic nude mice, indicating the relevance of its activity for cancer therapy. Twit Text FOAVip Exclusive destruction of mitotic spindles in human cancer cells ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=28209915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28209915 #FOAvip English Wikipedia <ref>{{Cite pmid|28209915}}</ref> Exclusive destruction of mitotic spindles in human cancer cells #MMPMID28209915 Visochek L; Castiel A; Mittelman L; Elkin M; Atias D; Golan T; Izraeli S; Peretz T; Cohen-Armon M Oncotarget 2017[Mar]; 8 (13): 20813-24 PMID28209915show ga We identified target proteins modified by phenanthrenes that cause exclusive eradication of human cancer cells. The cytotoxic activity of the phenanthrenes in a variety of human cancer cells is attributed by these findings to post translational modifications of NuMA and kinesins HSET/kifC1 and kif18A. Their activity prevented the binding of NuMA to ?-tubulin and kinesins in human cancer cells, and caused aberrant spindles. The most efficient cytotoxic activity of the phenanthridine PJ34, caused significantly smaller aberrant spindles with disrupted spindle poles and scattered extra-centrosomes and chromosomes. Concomitantly, PJ34 induced tumor growth arrest of human malignant tumors developed in athymic nude mice, indicating the relevance of its activity for cancer therapy. äExclusive destruction of mitotic spindles in human cancer cells (epmc).pdf DeepDyve Pubget Overpricing