Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.7554/eLife.25068 http://scihub22266oqcxt.onion/10.7554/eLife.25068 C5400505!5400505 !28430104     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28430104 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Elife 2017 ; 6 (ä): ä Nephropedia Template TP {{tp|p=28430104 |t=2017. Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD |pdf=|usr=}}{{28430104 }} gab.com Text Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=28430104 #FOAvip TEAD (TEA/ATTS domain) transcription factors are the most distal effectors of the Hippo pathway. YAP (Yes-associated protein) is a coactivator protein which, upon binding to TEAD proteins, stimulates their transcriptional activity. Since the Hippo pathway is deregulated in various cancers, designing inhibitors of the YAP:TEAD interaction is an attractive therapeutic strategy for oncology. Understanding the molecular events that take place at the YAP:TEAD interface is therefore important not only to devise drug discovery approaches, but also to gain knowledge on TEAD regulation. In this report, combining single site-directed mutagenesis and double mutant analyses, we conduct a detailed analysis on the role of several residues located at the YAP:TEAD interface. Our results provide quantitative understanding of the interactions taking place at the YAP:TEAD interface and give insights into the formation of the YAP:TEAD complex and more particularly on the interaction between TEAD and the ?-loop found in YAP. Twit Text FOAVip Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=28430104 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28430104 #FOAvip English Wikipedia <ref>{{Cite pmid|28430104 }}</ref> Dissection of the interaction between the intrinsically disordered YAP protein and the transcription factor TEAD #MMPMID28430104 Mesrouze Y ; Bokhovchuk F ; Meyerhofer M ; Fontana P ; Zimmermann C ; Martin T ; Delaunay C ; Erdmann D ; Schmelzle T ; Chène P Elife 2017[Apr]; 6 (ä): ä PMID28430104 show ga TEAD (TEA/ATTS domain) transcription factors are the most distal effectors of the Hippo pathway. YAP (Yes-associated protein) is a coactivator protein which, upon binding to TEAD proteins, stimulates their transcriptional activity. Since the Hippo pathway is deregulated in various cancers, designing inhibitors of the YAP:TEAD interaction is an attractive therapeutic strategy for oncology. Understanding the molecular events that take place at the YAP:TEAD interface is therefore important not only to devise drug discovery approaches, but also to gain knowledge on TEAD regulation. In this report, combining single site-directed mutagenesis and double mutant analyses, we conduct a detailed analysis on the role of several residues located at the YAP:TEAD interface. Our results provide quantitative understanding of the interactions taking place at the YAP:TEAD interface and give insights into the formation of the YAP:TEAD complex and more particularly on the interaction between TEAD and the ?-loop found in YAP. |*Protein Interaction Maps [MESH] |Adaptor Proteins, Signal Transducing/genetics/*metabolism [MESH] |DNA Mutational Analysis [MESH] |DNA-Binding Proteins/genetics/*metabolism [MESH] |Muscle Proteins/genetics/*metabolism [MESH] |Mutagenesis, Site-Directed [MESH] |Mutant Proteins/genetics/metabolism [MESH] |Phosphoproteins/genetics/*metabolism [MESH] |Protein Binding [MESH] |TEA Domain Transcription Factors [MESH] |Transcription Factors/genetics/*metabolism [MESH]Dissection of the interaction between the intrinsically disordered YAP(epmc).pdf DeepDyve Pubget Overpricing