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10.1093/eurheartj/ehw593 http://scihub22266oqcxt.onion/10.1093/eurheartj/ehw593 C5400074!5400074 !28369340     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28369340 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 332.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 332.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 332.4 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28369340 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Eur+Heart+J 2017 ; 38 (15 ): 1119-1127 Nephropedia Template TP {{tp|p=28369340 |t=2017. Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study |pdf=|usr=}}{{28369340 }} gab.com Text Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study JO: Eur Heart J http://www.kidney.de/pget.php?&tw=1&pmid=28369340 #FOAvip AIMS: To determine tolerability and the optimal dose regimen of the soluble guanylate cyclase stimulator vericiguat in patients with chronic heart failure and preserved ejection fraction (HFpEF). METHODS AND RESULTS: SOCRATES-PRESERVED was a prospective, randomized, placebo-controlled double-blind, Phase 2b dose-finding study in patients with HFpEF (ejection fraction?? 45%). Patients received vericiguat once daily at 1.25 or 2.5?mg fixed doses, or 5 or 10?mg titrated from a 2.5?mg starting dose, or placebo for 12 weeks. The two primary endpoints were change from baseline in log-transformed N-terminal pro-B-type natriuretic peptide (NT-ProBNP) and left atrial volume (LAV) at 12 weeks. Patients (N?=?477; 48% women; mean age 73?±?10 years; baseline atrial fibrillation 40%) were randomized within 4 weeks of HF hospitalization (75%) or outpatient treatment with intravenous diuretics for HF (25%) to vericiguat (n?=?384) or placebo (n?=?93). In the pooled three highest dose arms change in logNT-proBNP (vericiguat:?+0.038?±?0.782 log(pg/mL), n?=?195; placebo:?-0.098?±?0.778 log(pg/mL), n?=?73; one-sided P?=?0.8991, two-sided P?=?0.2017), and change in LAV [vericiguat: -1.7?±?12.8?mL (n?=?194); placebo: ?-3.4?±?12.7?mL (n?=?67), one-sided P?=?0.8156, two-sided P?=?0.3688] were not different from placebo. Vericiguat was well tolerated (adverse events: vericiguat 10?mg arm, 69.8%; placebo, 73.1%), with low discontinuation rates in all groups, and no changes in blood pressure at 10?mg compared with placebo. The pre-specified exploratory endpoint of Kansas City Cardiomyopathy Questionnaire Clinical Summary Score improved in the vericiguat 10?mg arm by mean 19.3?±?16.3 points [median 19.8 (interquartile range 10.4-30.7)] from baseline (mean difference from placebo 9.2 points). CONCLUSION: Vericiguat was well tolerated, did not change NT-proBNP and LAV at 12 weeks compared with placebo but was associated with improvements in quality of life in patients with HFpEF. Given the encouraging results on quality of life, the effects of vericiguat in patients with HFpEF warrant further study, possibly with higher doses, longer follow-up and additional endpoints. Twit Text FOAVip Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study ????Eur Heart J http://www.kidney.de/pget.php?&tw=1&pmid=28369340 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28369340 #FOAvip English Wikipedia <ref>{{Cite pmid|28369340 }}</ref> Vericiguat in patients with worsening chronic heart failure and preserved ejection fraction: results of the SOluble guanylate Cyclase stimulatoR in heArT failurE patientS with PRESERVED EF (SOCRATES-PRESERVED) study #MMPMID28369340 Pieske B ; Maggioni AP ; Lam CSP ; Pieske-Kraigher E ; Filippatos G ; Butler J ; Ponikowski P ; Shah SJ ; Solomon SD ; Scalise AV ; Mueller K ; Roessig L ; Gheorghiade M Eur Heart J 2017[Apr]; 38 (15 ): 1119-1127 PMID28369340 show ga AIMS: To determine tolerability and the optimal dose regimen of the soluble guanylate cyclase stimulator vericiguat in patients with chronic heart failure and preserved ejection fraction (HFpEF). METHODS AND RESULTS: SOCRATES-PRESERVED was a prospective, randomized, placebo-controlled double-blind, Phase 2b dose-finding study in patients with HFpEF (ejection fraction?? 45%). Patients received vericiguat once daily at 1.25 or 2.5?mg fixed doses, or 5 or 10?mg titrated from a 2.5?mg starting dose, or placebo for 12 weeks. The two primary endpoints were change from baseline in log-transformed N-terminal pro-B-type natriuretic peptide (NT-ProBNP) and left atrial volume (LAV) at 12 weeks. Patients (N?=?477; 48% women; mean age 73?±?10 years; baseline atrial fibrillation 40%) were randomized within 4 weeks of HF hospitalization (75%) or outpatient treatment with intravenous diuretics for HF (25%) to vericiguat (n?=?384) or placebo (n?=?93). In the pooled three highest dose arms change in logNT-proBNP (vericiguat:?+0.038?±?0.782 log(pg/mL), n?=?195; placebo:?-0.098?±?0.778 log(pg/mL), n?=?73; one-sided P?=?0.8991, two-sided P?=?0.2017), and change in LAV [vericiguat: -1.7?±?12.8?mL (n?=?194); placebo: ?-3.4?±?12.7?mL (n?=?67), one-sided P?=?0.8156, two-sided P?=?0.3688] were not different from placebo. Vericiguat was well tolerated (adverse events: vericiguat 10?mg arm, 69.8%; placebo, 73.1%), with low discontinuation rates in all groups, and no changes in blood pressure at 10?mg compared with placebo. The pre-specified exploratory endpoint of Kansas City Cardiomyopathy Questionnaire Clinical Summary Score improved in the vericiguat 10?mg arm by mean 19.3?±?16.3 points [median 19.8 (interquartile range 10.4-30.7)] from baseline (mean difference from placebo 9.2 points). CONCLUSION: Vericiguat was well tolerated, did not change NT-proBNP and LAV at 12 weeks compared with placebo but was associated with improvements in quality of life in patients with HFpEF. Given the encouraging results on quality of life, the effects of vericiguat in patients with HFpEF warrant further study, possibly with higher doses, longer follow-up and additional endpoints. |Aged [MESH] |Atrial Function, Left/drug effects [MESH] |Cardiotonic Agents/*administration & dosage/adverse effects [MESH] |Chronic Disease [MESH] |Dose-Response Relationship, Drug [MESH] |Double-Blind Method [MESH] |Drug Administration Schedule [MESH] |Female [MESH] |Heart Failure/*drug therapy/physiopathology [MESH] |Heterocyclic Compounds, 2-Ring/*administration & dosage/adverse effects [MESH] |Humans [MESH] |Male [MESH] |Natriuretic Peptide, Brain/metabolism [MESH] |Peptide Fragments/metabolism [MESH] |Prospective Studies [MESH] |Pyrimidines/*administration & dosage/adverse effects [MESH] |Soluble Guanylyl Cyclase/*administration & dosage/adverse effects [MESH] |Stroke Volume/physiology [MESH]Vericiguat in patients with worsening chronic heart failure and preser(epmc).pdf DeepDyve Pubget Overpricing