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10.12659/msm.900406 http://scihub22266oqcxt.onion/10.12659/msm.900406 C5400029!5400029 !28410362     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28410362 &cmd=llinks): Failed to open stream: HTTP request failed! 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Joint Assessment of Donor and Recipient hTERT Gene Polymorphism Provides Additional Information for Early Kidney Transplantation Outcomes |pdf=|usr=}}{{28410362 }} gab.com Text Joint Assessment of Donor and Recipient hTERT Gene Polymorphism Provides Additional Information for Early Kidney Transplantation Outcomes JO: Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=28410362 #FOAvip BACKGROUND There are several genes and genetic loci affecting telomere length, including hTERT gene and BICD1 gene as well as polymorphisms within chromosome 18. It has been demonstrated that the age of the donor is a negative factor associated with long-term kidney allograft function, and that post-transplant complications accelerate transplanted organ aging, thus contributing to estimated glomerular filtration rate (eGFR) decreases. The aim of this study was a joint assessment of donors' and recipients' hTERT and BICD1 genes as well as chromosome 18 polymorphisms with regard to early kidney transplantation outcomes. MATERIAL AND METHODS The study enrolled 74 pairs of Polish Caucasian kidney allograft cadaveric donors (60% male, mean age 45.99±14.62) and recipients (50.0% male, mean age 48.89±13.50). The transplantation procedure (Tx) was performed between 2001 and 2012. All samples were genotyped in duplicate using Real-Time PCR. RESULTS This study showed that rs2735940 hTERT CX-TT donor-recipient genotype pair was associated with almost five times higher odds (OR=4.82; 95% CI: 1.32-18; p=0.016) of delayed graft function (DGF), and that rs2735940 hTERT, rs2630578 BICD1, and rs7235755 chromosome 18 polymorphisms combined pairs were not associated with acute rejection (AR). CONCLUSIONS In conclusion, both the donor's and the recipient's rs2735940 hTERT gene polymorphism was associated with early graft function after transplantation. The odds of DGF were almost five times higher for a combination of CX (CT or CC) donor genotype and TT recipient genotype. Joint assessment of donor-recipient genotype pairs provides more information for prediction of early kidney transplantation outcomes. Twit Text FOAVip Joint Assessment of Donor and Recipient hTERT Gene Polymorphism Provides Additional Information for Early Kidney Transplantation Outcomes ????Med Sci Monit http://www.kidney.de/pget.php?&tw=1&pmid=28410362 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28410362 #FOAvip English Wikipedia <ref>{{Cite pmid|28410362 }}</ref> Joint Assessment of Donor and Recipient hTERT Gene Polymorphism Provides Additional Information for Early Kidney Transplantation Outcomes #MMPMID28410362 K?oda K ; Mierzecki A ; Doma?ski L ; Borowiecka E ; Safranow K ; Ciechanowicz A ; Ciechanowski K Med Sci Monit 2017[Apr]; 23 (ä): 1812-1818 PMID28410362 show ga BACKGROUND There are several genes and genetic loci affecting telomere length, including hTERT gene and BICD1 gene as well as polymorphisms within chromosome 18. It has been demonstrated that the age of the donor is a negative factor associated with long-term kidney allograft function, and that post-transplant complications accelerate transplanted organ aging, thus contributing to estimated glomerular filtration rate (eGFR) decreases. The aim of this study was a joint assessment of donors' and recipients' hTERT and BICD1 genes as well as chromosome 18 polymorphisms with regard to early kidney transplantation outcomes. MATERIAL AND METHODS The study enrolled 74 pairs of Polish Caucasian kidney allograft cadaveric donors (60% male, mean age 45.99±14.62) and recipients (50.0% male, mean age 48.89±13.50). The transplantation procedure (Tx) was performed between 2001 and 2012. All samples were genotyped in duplicate using Real-Time PCR. RESULTS This study showed that rs2735940 hTERT CX-TT donor-recipient genotype pair was associated with almost five times higher odds (OR=4.82; 95% CI: 1.32-18; p=0.016) of delayed graft function (DGF), and that rs2735940 hTERT, rs2630578 BICD1, and rs7235755 chromosome 18 polymorphisms combined pairs were not associated with acute rejection (AR). CONCLUSIONS In conclusion, both the donor's and the recipient's rs2735940 hTERT gene polymorphism was associated with early graft function after transplantation. The odds of DGF were almost five times higher for a combination of CX (CT or CC) donor genotype and TT recipient genotype. Joint assessment of donor-recipient genotype pairs provides more information for prediction of early kidney transplantation outcomes. |Adaptor Proteins, Signal Transducing/*genetics/metabolism [MESH] |Adult [MESH] |Chromosomes, Human, Pair 18 [MESH] |Cytoskeletal Proteins/*genetics/metabolism [MESH] |Delayed Graft Function/genetics/metabolism [MESH] |Female [MESH] |Genotype [MESH] |Glomerular Filtration Rate [MESH] |Graft Rejection/genetics/metabolism [MESH] |Humans [MESH] |Kidney Transplantation/*methods [MESH] |Male [MESH] |Middle Aged [MESH] |Polymorphism, Genetic [MESH] |Telomerase/*genetics/metabolism [MESH] |Telomere/genetics/metabolism [MESH] |Tissue Donors [MESH] |Transplantation, Homologous [MESH]Joint Assessment of Donor and Recipient hTERT Gene Polymorphism Provid(epmc).pdf DeepDyve Pubget Overpricing