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10.1242/dev.148494 http://scihub22266oqcxt.onion/10.1242/dev.148494 C5399671!5399671!28264836     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Development 2017 ; 144 (8): 1531-43 Nephropedia Template TP {{tp|p=28264836|t=2017. A systems-level approach reveals new gene regulatory modules in the developing ear |pdf=|usr=}}{{28264836}} gab.com Text A systems-level approach reveals new gene regulatory modules in the developing ear JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=28264836 #FOAvip The inner ear is a complex vertebrate sense organ, yet it arises from a simple epithelium, the otic placode. Specification towards otic fate requires diverse signals and transcriptional inputs that act sequentially and/or in parallel. Using the chick embryo, we uncover novel genes in the gene regulatory network underlying otic commitment and reveal dynamic changes in gene expression. Functional analysis of selected transcription factors reveals the genetic hierarchy underlying the transition from progenitor to committed precursor, integrating known and novel molecular players. Our results not only characterize the otic transcriptome in unprecedented detail, but also identify new gene interactions responsible for inner ear development and for the segregation of the otic lineage from epibranchial progenitors. By recapitulating the embryonic programme, the genes and genetic sub-circuits discovered here might be useful for reprogramming naïve cells towards otic identity to restore hearing loss. Twit Text FOAVip A systems-level approach reveals new gene regulatory modules in the developing ear ????Development http://www.kidney.de/pget.php?&tw=1&pmid=28264836 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28264836 #FOAvip English Wikipedia <ref>{{Cite pmid|28264836}}</ref> A systems-level approach reveals new gene regulatory modules in the developing ear #MMPMID28264836 Chen J; Tambalo M; Barembaum M; Ranganathan R; Simões-Costa M; Bronner ME; Streit A Development 2017[Apr]; 144 (8): 1531-43 PMID28264836show ga The inner ear is a complex vertebrate sense organ, yet it arises from a simple epithelium, the otic placode. Specification towards otic fate requires diverse signals and transcriptional inputs that act sequentially and/or in parallel. Using the chick embryo, we uncover novel genes in the gene regulatory network underlying otic commitment and reveal dynamic changes in gene expression. Functional analysis of selected transcription factors reveals the genetic hierarchy underlying the transition from progenitor to committed precursor, integrating known and novel molecular players. Our results not only characterize the otic transcriptome in unprecedented detail, but also identify new gene interactions responsible for inner ear development and for the segregation of the otic lineage from epibranchial progenitors. By recapitulating the embryonic programme, the genes and genetic sub-circuits discovered here might be useful for reprogramming naïve cells towards otic identity to restore hearing loss. äA systems-level approach reveals new gene regulatory modules in the de(epmc).pdf DeepDyve Pubget Overpricing