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10.1242/dev.142711 http://scihub22266oqcxt.onion/10.1242/dev.142711 C5399622!5399622!28174249     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28174249&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Development 2017 ; 144 (7): 1221-34 Nephropedia Template TP {{tp|p=28174249|t=2017. Tracking the embryonic stem cell transition from ground state pluripotency |pdf=|usr=}}{{28174249}} gab.com Text Tracking the embryonic stem cell transition from ground state pluripotency JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=28174249 #FOAvip Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a system for delineating developmental progression from naïve pluripotency. Here, we examine the initial transition process. The ES cell population behaves asynchronously. We therefore exploited a short-half-life Rex1::GFP reporter to isolate cells either side of exit from naïve status. Extinction of ES cell identity in single cells is acute. It occurs only after near-complete elimination of naïve pluripotency factors, but precedes appearance of lineage specification markers. Cells newly departed from the ES cell state display features of early post-implantation epiblast and are distinct from primed epiblast. They also exhibit a genome-wide increase in DNA methylation, intermediate between early and late epiblast. These findings are consistent with the proposition that naïve cells transition to a distinct formative phase of pluripotency preparatory to lineage priming. Twit Text FOAVip Tracking the embryonic stem cell transition from ground state pluripotency ????Development http://www.kidney.de/pget.php?&tw=1&pmid=28174249 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28174249 #FOAvip English Wikipedia <ref>{{Cite pmid|28174249}}</ref> Tracking the embryonic stem cell transition from ground state pluripotency #MMPMID28174249 Kalkan T; Olova N; Roode M; Mulas C; Lee HJ; Nett I; Marks H; Walker R; Stunnenberg HG; Lilley KS; Nichols J; Reik W; Bertone P; Smith A Development 2017[Apr]; 144 (7): 1221-34 PMID28174249show ga Mouse embryonic stem (ES) cells are locked into self-renewal by shielding from inductive cues. Release from this ground state in minimal conditions offers a system for delineating developmental progression from naïve pluripotency. Here, we examine the initial transition process. The ES cell population behaves asynchronously. We therefore exploited a short-half-life Rex1::GFP reporter to isolate cells either side of exit from naïve status. Extinction of ES cell identity in single cells is acute. It occurs only after near-complete elimination of naïve pluripotency factors, but precedes appearance of lineage specification markers. Cells newly departed from the ES cell state display features of early post-implantation epiblast and are distinct from primed epiblast. They also exhibit a genome-wide increase in DNA methylation, intermediate between early and late epiblast. These findings are consistent with the proposition that naïve cells transition to a distinct formative phase of pluripotency preparatory to lineage priming. äTracking the embryonic stem cell transition from ground state pluripot(epmc).pdf DeepDyve Pubget Overpricing