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10.2337/db16-0887 http://scihub22266oqcxt.onion/10.2337/db16-0887 C5399608!5399608!28223284     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diabetes 2017 ; 66 (5): 1293-300 Nephropedia Template TP {{tp|p=28223284|t=2017. Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet ?-Cells Into ?-Cells In Vivo |pdf=|usr=}}{{28223284}} gab.com Text Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet -Cells Into -Cells In Vivo JO: Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=28223284 #FOAvip Among the therapeutic avenues being explored for replacement of the functional islet ?-cell mass lost in type 1 diabetes (T1D), reprogramming of adult cell types into new ?-cells has been actively pursued. Notably, mouse islet ?-cells will transdifferentiate into ?-cells under conditions of near ?-cell loss, a condition similar to T1D. Moreover, human islet ?-cells also appear to poised for reprogramming into insulin-positive cells. Here we have generated transgenic mice conditionally expressing the islet ?-cell?enriched Mafa and/or Pdx1 transcription factors to examine their potential to transdifferentiate embryonic pan?islet cell Ngn3-positive progenitors and the later glucagon-positive ?-cell population into ?-cells. Mafa was found to both potentiate the ability of Pdx1 to induce ?-cell formation from Ngn3-positive endocrine precursors and enable Pdx1 to produce ?-cells from ?-cells. These results provide valuable insight into the fundamental mechanisms influencing islet cell plasticity in vivo. Twit Text FOAVip Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet -Cells Into -Cells In Vivo ????Diabetes http://www.kidney.de/pget.php?&tw=1&pmid=28223284 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28223284 #FOAvip English Wikipedia <ref>{{Cite pmid|28223284}}</ref> Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet ?-Cells Into ?-Cells In Vivo #MMPMID28223284 Matsuoka Ta; Kawashima S; Miyatsuka T; Sasaki S; Shimo N; Katakami N; Kawamori D; Takebe S; Herrera PL; Kaneto H; Stein R; Shimomura I Diabetes 2017[May]; 66 (5): 1293-300 PMID28223284show ga Among the therapeutic avenues being explored for replacement of the functional islet ?-cell mass lost in type 1 diabetes (T1D), reprogramming of adult cell types into new ?-cells has been actively pursued. Notably, mouse islet ?-cells will transdifferentiate into ?-cells under conditions of near ?-cell loss, a condition similar to T1D. Moreover, human islet ?-cells also appear to poised for reprogramming into insulin-positive cells. Here we have generated transgenic mice conditionally expressing the islet ?-cell?enriched Mafa and/or Pdx1 transcription factors to examine their potential to transdifferentiate embryonic pan?islet cell Ngn3-positive progenitors and the later glucagon-positive ?-cell population into ?-cells. Mafa was found to both potentiate the ability of Pdx1 to induce ?-cell formation from Ngn3-positive endocrine precursors and enable Pdx1 to produce ?-cells from ?-cells. These results provide valuable insight into the fundamental mechanisms influencing islet cell plasticity in vivo. äMafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors (epmc).pdf DeepDyve Pubget Overpricing