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10.7150/thno.17908 http://scihub22266oqcxt.onion/10.7150/thno.17908 C5399576!5399576!28435448     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Theranostics 2017 ; 7 (5): 1062-71 Nephropedia Template TP {{tp|p=28435448|t=2017. Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis |pdf=|usr=}}{{28435448}} gab.com Text Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis JO: Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=28435448 #FOAvip Extensive evidence has shown that platelets support tumor metastatic progression by inducing epithelial-mesenchymal transition of cancer cells and by shielding circulating tumor cells from immune-mediated elimination. Therefore, blocking platelet function represents a potential new avenue for therapy focused on eliminating metastasis. Here we show that liposomal nanoparticles bearing the tumor-homing pentapeptide CREKA (Cys-Arg-Glu-Lys-Ala) can deliver a platelet inhibitor, ticagrelor, into tumor tissues to specifically inhibit tumor-associated platelets. The drug-loaded nanoparticles (CREKA-Lipo-T) efficiently blocked the platelet-induced acquisition of an invasive phenotype by tumor cells and inhibited platelet-tumor cell interaction in vitro. Intravenously administered CREKA-Lipo-T effectively targeted tumors within 24 h, and inhibited tumor metastasis without overt side effects. Thus, the CREKA-Lipo formulation provides a simple strategy for the efficient delivery of anti-metastatic drugs and shows considerable promise as a platform for novel cancer therapeutics. Twit Text FOAVip Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis ????Theranostics http://www.kidney.de/pget.php?&tw=1&pmid=28435448 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28435448 #FOAvip English Wikipedia <ref>{{Cite pmid|28435448}}</ref> Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis #MMPMID28435448 Zhang Y; Wei J; Liu S; Wang J; Han X; Qin H; Lang J; Cheng K; Li Y; Qi Y; Anderson GJ; Sukumar S; Li S; Nie G Theranostics 2017[]; 7 (5): 1062-71 PMID28435448show ga Extensive evidence has shown that platelets support tumor metastatic progression by inducing epithelial-mesenchymal transition of cancer cells and by shielding circulating tumor cells from immune-mediated elimination. Therefore, blocking platelet function represents a potential new avenue for therapy focused on eliminating metastasis. Here we show that liposomal nanoparticles bearing the tumor-homing pentapeptide CREKA (Cys-Arg-Glu-Lys-Ala) can deliver a platelet inhibitor, ticagrelor, into tumor tissues to specifically inhibit tumor-associated platelets. The drug-loaded nanoparticles (CREKA-Lipo-T) efficiently blocked the platelet-induced acquisition of an invasive phenotype by tumor cells and inhibited platelet-tumor cell interaction in vitro. Intravenously administered CREKA-Lipo-T effectively targeted tumors within 24 h, and inhibited tumor metastasis without overt side effects. Thus, the CREKA-Lipo formulation provides a simple strategy for the efficient delivery of anti-metastatic drugs and shows considerable promise as a platform for novel cancer therapeutics. äInhibition of platelet function using liposomal nanoparticles blocks t(epmc).pdf DeepDyve Pubget Overpricing