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10.1038/srep46581 http://scihub22266oqcxt.onion/10.1038/srep46581 C5399488!5399488 !28429726     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28429726 &cmd=llinks): Failed to open stream: HTTP request failed! 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Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity |pdf=|usr=}}{{28429726 }} gab.com Text Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28429726 #FOAvip Verteporfin (VP) was first used in Photodynamic therapy, where a non-thermal laser light (689?nm) in the presence of oxygen activates the drug to produce highly reactive oxygen radicals, resulting in local cell and tissue damage. However, it has also been shown that Verteporfin can have non-photoactivated effects such as interference with the YAP-TEAD complex of the HIPPO pathway, resulting in growth inhibition of several neoplasias. More recently, it was proposed that, another non-light mediated effect of VP is the formation of cross-linked oligomers and high molecular weight protein complexes (HMWC) that are hypothesized to interfere with autophagy and cell growth. Here, in a series of experiments, using human uveal melanoma cells (MEL 270), human embryonic kidney cells (HEK) and breast cancer cells (MCF7) we showed that Verteporfin-induced HMWC require the presence of light. Furthermore, we showed that the mechanism of this cross-linking, which involves both singlet oxygen and radical generation, can occur very efficiently even after lysis of the cells, if the lysate is not protected from ambient light. This work offers a better understanding regarding VP's mechanisms of action and suggests caution when one studies the non-light mediated actions of this drug. Twit Text FOAVip Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28429726 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28429726 #FOAvip English Wikipedia <ref>{{Cite pmid|28429726 }}</ref> Verteporfin-induced formation of protein cross-linked oligomers and high molecular weight complexes is mediated by light and leads to cell toxicity #MMPMID28429726 Konstantinou EK ; Notomi S ; Kosmidou C ; Brodowska K ; Al-Moujahed A ; Nicolaou F ; Tsoka P ; Gragoudas E ; Miller JW ; Young LH ; Vavvas DG Sci Rep 2017[Apr]; 7 (ä): 46581 PMID28429726 show ga Verteporfin (VP) was first used in Photodynamic therapy, where a non-thermal laser light (689?nm) in the presence of oxygen activates the drug to produce highly reactive oxygen radicals, resulting in local cell and tissue damage. However, it has also been shown that Verteporfin can have non-photoactivated effects such as interference with the YAP-TEAD complex of the HIPPO pathway, resulting in growth inhibition of several neoplasias. More recently, it was proposed that, another non-light mediated effect of VP is the formation of cross-linked oligomers and high molecular weight protein complexes (HMWC) that are hypothesized to interfere with autophagy and cell growth. Here, in a series of experiments, using human uveal melanoma cells (MEL 270), human embryonic kidney cells (HEK) and breast cancer cells (MCF7) we showed that Verteporfin-induced HMWC require the presence of light. Furthermore, we showed that the mechanism of this cross-linking, which involves both singlet oxygen and radical generation, can occur very efficiently even after lysis of the cells, if the lysate is not protected from ambient light. This work offers a better understanding regarding VP's mechanisms of action and suggests caution when one studies the non-light mediated actions of this drug. |*Light [MESH] |*Neoplasms/drug therapy/metabolism/pathology [MESH] |*Photochemotherapy [MESH] |*Photosensitizing Agents/pharmacokinetics/pharmacology [MESH] |*Verteporfin/pharmacokinetics/pharmacology [MESH] |Adaptor Proteins, Signal Transducing/metabolism [MESH] |DNA-Binding Proteins/metabolism [MESH] |HEK293 Cells [MESH] |Hippo Signaling Pathway [MESH] |Humans [MESH] |MCF-7 Cells [MESH] |Multiprotein Complexes/*metabolism [MESH] |Phosphoproteins/metabolism [MESH] |Protein Serine-Threonine Kinases/metabolism [MESH] |Transcription Factors [MESH]Verteporfin-induced formation of protein cross-linked oligomers and hi(epmc).pdf DeepDyve Pubget Overpricing