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10.1186/s13048-017-0325-4 http://scihub22266oqcxt.onion/10.1186/s13048-017-0325-4 C5399399!5399399!28427435     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Ovarian+Res 2017 ; 10 (ä): ä Nephropedia Template TP {{tp|p=28427435|t=2017. Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-? pathways |pdf=|usr=}}{{28427435}} gab.com Text Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF- pathways JO: J Ovarian Res http://www.kidney.de/pget.php?&tw=1&pmid=28427435 #FOAvip Background: Ovarian epithelial tumor (OET) is a silent disease of late diagnosis and poor prognosis. Currently treatment options are limited and patient response to treatment is difficult to predict so there is a serious need to delineate the real pathogenesis to predict tumour prognosis. Prohibitin (PHB) is an evolutionarily protein that regulates the cell cycle. TGF-? has been shown to be a positive and negative regulator of cellular proliferation and differentiation.The present study provides an overview on the role played by PHB1, TGF-? and LH in ovarian cancer. Methods: The study was conducted on 60 patients with ovarian tumors (benign, borderline and malignant) and 20 healthy volunteers. LH and TGF-? serum levels were measured by ELISA. Expression of prohibitin and LHR-mRNA were assessed by IHC and TaqMan® real time gene expression assay, respectively. Results: Serum levels of LH and TGF-? were significantly decreased among borderline and malignant groups. There was significant over-expression of LHRmRNA in malignant group. Prohibitin expression was significantly increased in malignant ovarian tissue. Strong negative correlations were found between LHR mRNA expression and serum LH levels, and between IHC score of prohibitin and serum levels of LH among patients with borderline ovarian tumors. Conclusion: Steady decline of LH and TGF-B serum levels, from benign cystadenoma to borderline tumor to carcinoma, suggests their inhibitory role against OET cell growth. Increased PHB1 expression in OET suggests its proliferative activity that can be regulated by luteinisation and/or TGF-?. Furthermore increased LHR mRNA tissue expression can provide hope for using LH in treatment of some types of ovarian cancers. Twit Text FOAVip Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF- pathways ????J Ovarian Res http://www.kidney.de/pget.php?&tw=1&pmid=28427435 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28427435 #FOAvip English Wikipedia <ref>{{Cite pmid|28427435}}</ref> Prohibitin: targeting peptide coupled to ovarian cancer, luteinization and TGF-? pathways #MMPMID28427435 El-Etreby NM; Ghazy AA; Rashad R J Ovarian Res 2017[]; 10 (ä): ä PMID28427435show ga Background: Ovarian epithelial tumor (OET) is a silent disease of late diagnosis and poor prognosis. Currently treatment options are limited and patient response to treatment is difficult to predict so there is a serious need to delineate the real pathogenesis to predict tumour prognosis. Prohibitin (PHB) is an evolutionarily protein that regulates the cell cycle. TGF-? has been shown to be a positive and negative regulator of cellular proliferation and differentiation.The present study provides an overview on the role played by PHB1, TGF-? and LH in ovarian cancer. Methods: The study was conducted on 60 patients with ovarian tumors (benign, borderline and malignant) and 20 healthy volunteers. LH and TGF-? serum levels were measured by ELISA. Expression of prohibitin and LHR-mRNA were assessed by IHC and TaqMan® real time gene expression assay, respectively. Results: Serum levels of LH and TGF-? were significantly decreased among borderline and malignant groups. There was significant over-expression of LHRmRNA in malignant group. Prohibitin expression was significantly increased in malignant ovarian tissue. Strong negative correlations were found between LHR mRNA expression and serum LH levels, and between IHC score of prohibitin and serum levels of LH among patients with borderline ovarian tumors. Conclusion: Steady decline of LH and TGF-B serum levels, from benign cystadenoma to borderline tumor to carcinoma, suggests their inhibitory role against OET cell growth. Increased PHB1 expression in OET suggests its proliferative activity that can be regulated by luteinisation and/or TGF-?. Furthermore increased LHR mRNA tissue expression can provide hope for using LH in treatment of some types of ovarian cancers. äProhibitin: targeting peptide coupled to ovarian cancer, luteinization(epmc).pdf DeepDyve Pubget Overpricing