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10.1038/srep46485 http://scihub22266oqcxt.onion/10.1038/srep46485 C5399373!5399373 !28429725     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28429725 &cmd=llinks): Failed to open stream: HTTP request failed! 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Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution |pdf=|usr=}}{{28429725 }} gab.com Text Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28429725 #FOAvip Epidemiological studies have indicated increased risk for breast cancer within 10 years of childbirth. Acute inflammation during mammary involution has been suggested to promote this parity-associated breast cancer. We report here that estrogen exacerbates mammary inflammation during involution. Microarray analysis shows that estrogen induces an extensive proinflammatory gene signature in the involuting mammary tissue. This is associated with estrogen-induced neutrophil infiltration. Furthermore, estrogen induces the expression of protumoral cytokines/chemokines, COX-2 and tissue-remodeling enzymes in isolated mammary neutrophils and systemic neutrophil depletion abolished estrogen-induced expression of these genes in mammary tissue. More interestingly, neutrophil depletion diminished estrogen-induced growth of ER?-negative mammary tumor 4T1 in Balb/c mice. These findings highlight a novel aspect of estrogen action that reprograms the activity of neutrophils to create a pro-tumoral microenvironment during mammary involution. This effect on the microenvironment would conceivably aggravate its known neoplastic effect on mammary epithelial cells. Twit Text FOAVip Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=28429725 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28429725 #FOAvip English Wikipedia <ref>{{Cite pmid|28429725 }}</ref> Estrogen reprograms the activity of neutrophils to foster protumoral microenvironment during mammary involution #MMPMID28429725 Chung HH ; Or YZ ; Shrestha S ; Loh JT ; Lim CL ; Ong Z ; Woo ARE ; Su IH ; Lin VCL Sci Rep 2017[Apr]; 7 (ä): 46485 PMID28429725 show ga Epidemiological studies have indicated increased risk for breast cancer within 10 years of childbirth. Acute inflammation during mammary involution has been suggested to promote this parity-associated breast cancer. We report here that estrogen exacerbates mammary inflammation during involution. Microarray analysis shows that estrogen induces an extensive proinflammatory gene signature in the involuting mammary tissue. This is associated with estrogen-induced neutrophil infiltration. Furthermore, estrogen induces the expression of protumoral cytokines/chemokines, COX-2 and tissue-remodeling enzymes in isolated mammary neutrophils and systemic neutrophil depletion abolished estrogen-induced expression of these genes in mammary tissue. More interestingly, neutrophil depletion diminished estrogen-induced growth of ER?-negative mammary tumor 4T1 in Balb/c mice. These findings highlight a novel aspect of estrogen action that reprograms the activity of neutrophils to create a pro-tumoral microenvironment during mammary involution. This effect on the microenvironment would conceivably aggravate its known neoplastic effect on mammary epithelial cells. |*Cellular Reprogramming [MESH] |*Tumor Microenvironment [MESH] |Animals [MESH] |Cell Line, Tumor [MESH] |Estrogens/*metabolism [MESH] |Female [MESH] |Gene Expression Regulation, Neoplastic [MESH] |Mammary Glands, Animal/*metabolism/pathology [MESH] |Mammary Neoplasms, Experimental/*metabolism/pathology [MESH] |Mice [MESH] |Mice, Inbred BALB C [MESH] |Neoplasm Proteins/biosynthesis [MESH]Estrogen reprograms the activity of neutrophils to foster protumoral (epmc).pdf DeepDyve Pubget Overpricing